PMID: 7939728Jun 1, 1994Paper

Histological appearance of the synovium in early rheumatoid arthritis

Seminars in Arthritis and Rheumatism
H R SchumacherE P Gall


This report reviews and discusses studies on the synovial fluid and biopsy specimens of synovial membrane obtained during the first 6 weeks of synovitis that evolved into rheumatoid arthritis (RA). Five previously unreported cases are described. Early changes in the microvasculature and synovial lining seem to antedate the classical chronic inflammation of established RA. Further characterization in the joint tissues in very early RA offers opportunities for identification of exogenous triggers and may allow more appropriate targeting of early therapy to potentially reversible aspects of pathogenesis.


Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruth FritschGünter Steiner
Aug 2, 2012·Ultrastructural Pathology·Li Yun ZhangH Ralph Schumacher
Jul 21, 1998·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·Y Farhey, M Luggen
Feb 20, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Bruce M Rothschild
Sep 21, 2001·Immunology and Cell Biology·R A CarterI P Wicks
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Dec 25, 2002·Medicinal Research Reviews·Shaker A Mousa

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