Abstract
The clinical impact of pathological classification based on architectural pattern in hepatocellular carcinoma (HCC) remains elusive in spite of its well-known and common feature. The prognostic impact of pathological classification was examined with prospective database. Three hundred and eighty HCC patients who underwent curative hepatectomy as an initial treatment in Kumamoto University were enrolled as a test cohort. The outcome was confirmed with a validation cohort in Kyushu University. Macrotrabecular (macro-T) subtype (n = 38) and compact subtype (n = 43) showed similar biological and prognostic features. Both showed higher AFP level and worse overall survival than microrabecular (micro-T) subtype (n = 266). Multivariate analysis for overall survival revealed that DCP ≥ 40, multiple tumor and macro-T/compact subtype were associated with poor overall survival (risk ratio = 2.2, 1.6 and 1.6; p = 0.002, 0.020, and 0.047, respectively). Of note, 32% of macro-T/compact subtype showed early recurrence within 1 year, which showed substantially low (5%) 5 year overall survival, whereas 16% of micro-T/PG subtype did. Twenty-one percent of macro-T/compact subtype showed multiple intrahepatic metastases (≥ 4) or distant metastases,...Continue Reading
References
Feb 24, 2001·Medical Decision Making : an International Journal of the Society for Medical Decision Making·E W SteyerbergJ D Habbema
Jan 5, 2002·The American Journal of Surgical Pathology·Gregory Y LauwersUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
Jan 25, 2006·Annals of Surgery·Nazario PortolaniStefano Maria Giulini
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Dec 20, 2008·The Lancet Oncology·Ann-Lii ChengZhongzhen Guan
Jan 20, 2009·Gastroenterology·Taro YamashitaXin Wei Wang
Dec 21, 2010·International Journal of Cancer. Journal International Du Cancer·Scott M WilhelmDieter Zopf
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
May 25, 2011·Annals of Surgery·Shigehisa KiriyamaHiroki Yamaue
Feb 1, 2012·Oncotarget·Paul C McDonaldShoukat Dedhar
Nov 14, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hideki IjichiYoshihiko Maehara
Jul 11, 2014·Journal of Hepatology·Andrea PerraAmedeo Columbano
Aug 15, 2014·Seminars in Cancer Biology·Jaromir Pastorek, Silvia Pastorekova
Jun 11, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Poh Seng TanYujin Hoshida
Jun 24, 2015·Gastroenterology·Jessica Zucman-RossiJosep M Llovet
Sep 13, 2015·The Lancet Oncology·Jordi BruixUNKNOWN STORM investigators
Nov 20, 2015·Journal of Pathology and Translational Medicine·Jong Jin SungWoo Sung Moon
Jan 13, 2016·Journal of Cellular and Molecular Medicine·Yan LuMengsen Li
Oct 19, 2016·Journal of Hepatology·Kornelius SchulzeAugusto Villanueva
Oct 28, 2016·JAMA Oncology·Karim ChamieArie S Belldegrun
Dec 10, 2016·Lancet·Jordi BruixUNKNOWN RESORCE Investigators
Jan 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daimin XiangJin Ding
Citations
Feb 28, 2019·Histopathology·Makiko AdachiShinichi Aishima
May 6, 2019·International Journal of Computer Assisted Radiology and Surgery·Akira YamadaYasunari Fujinaga
Nov 25, 2019·Surgery Today·Hatem A ElmezayenHideo Baba
Nov 13, 2020·EBioMedicine·Kai-Qian ZhouXin-Rong Yang
Apr 28, 2021·Human Pathology·Deepika KumarXuchen Zhang
Jun 7, 2021·Annals of Surgical Oncology·Junji KawasakiMasaki Mori