Histological aspects of skin reactions to propylene glycol

Contact Dermatitis
J P NaterP J Hoedemaeker

Abstract

In view of the increased use of dermatological preparations containing a high concentration of propylene glycol (PG) for use under occlusive dressings, patch tests were performed with pure PG in a group of 98 out-patients at a skin clinic. No indication of a possible allergic contact dermatitis to PG could be found in the history of any of these patients. In 11 of them, the patch test reactions after a 48-h application were positive. In eight cases the reaction was scored as one plus, in two cases as two plus, and in the remaining case a three plus reaction was observed. In view of the negative history of all patients, the observed reactions were considered to be of a primary irritant nature. Histological examination of the positive patch tests revealed some definite quantitative differences between one and two plus reactions on the one hand and a three plus reaction on the other. The findings suggest that the application of high concentrations of PG under occlusive dressings may give rise to skin reactions of a primary irritant character which may closely simulate an allergic reaction.

References

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Citations

Nov 15, 2005·Contact Dermatitis·Holger LessmannWolfgang Uter
Feb 1, 1989·The Journal of Pharmacy and Pharmacology·U T LashmarN Thomas
Apr 1, 1982·International Journal of Cosmetic Science·J P GuillotJ Y Guyot
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Mar 7, 2013·International Journal of Pharmaceutics·Majella E Lane
Jul 26, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·William J FasanoNigel P Moore
Feb 12, 2014·Restorative Dentistry & Endodontics·Jin-Woo KimSuk-Keun Lee
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Related Concepts

Dressings, Spray-On
Patch Tests
Propylene Glycols
Skin

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