Histological assessment of bioengineered new bone in repairing osteoperiosteal mandibular defects in sheep using recombinant human bone morphogenetic protein-7

The British Journal of Oral & Maxillofacial Surgery
Muammar Abu-SerriahR H Fleming

Abstract

Numerous experimental studies have been published about osteoinductive bone morphogenetic proteins (BMPs). However, to our knowledge there has been no detailed histological study of a mandibular defect in a large mammal, reconstructed using BMPs. We describe here the histological features of rhBMP-7-induced bone in mandibular defects in sheep. A 35 mm osteoperiosteal defect was created at the parasymphyseal region of the mandible in six adult sheep. The continuity of the mandible was maintained using a bony plate, and rhBMP-7 was applied on a type I collagen carrier. Bone labels were injected at selected time intervals during the follow-up period. The animals were killed after 3 months and bone samples were examined histologically, histomorphometrically, and by fluorescence microscopy. We found a mixture of woven and lamellar bone that contained many cells with large nuclei. This had not reorganised to form cortical bone and the rhBMP-7-induced bone was more porous than the native bone. The newly-formed bone restored both endosteal and periosteal layers. rhBMP-7-induced bone was biocompatible and induced no ossification of soft tissue or abnormal growth of nearby vital structures. The mineral apposition rate was 1.98 microm/day...Continue Reading

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Citations

Feb 24, 2016·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Patricia L CarlislePamela R Brown Baer
Apr 18, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Kurt Busuttil NaudiJoseph Barbenel
May 26, 2009·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Société d'oto-laryngologie des hôpitaux de Paris·F JegouxG Daculsi
Sep 8, 2007·International Journal of Oral and Maxillofacial Surgery·A AyoubE Odell
Sep 3, 2011·Journal of Zhejiang University. Science. B·Yun-feng LiuWei Peng
Oct 1, 2016·Bio-medical Materials and Engineering·Ujjal K BhawalNorihiro Nishiyama
Aug 14, 2018·Journal of Molecular Histology·Zhenhua GaoSonglin Wang

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