PMID: 8944611Nov 1, 1996Paper

Histological assessment of chronic pancreatitis at necropsy

Journal of Clinical Pathology
M ShimizuT Manabe

Abstract

To evaluate the histological criteria used to diagnose chronic pancreatitis; and to assess interobserver variation among general pathologists. Forty five cases of chronic pancreatitis diagnosed in necropsy were reviewed to determine whether the diagnosis was acceptable retrospectively. These cases were diagnosed initially as chronic pancreatitis in the final necropsy report complied by general pathologists. In reviewing these cases, special attention was paid to irregular fibrosis and destruction of the lobular architecture. The 45 cases were re-assigned to seven different diagnostic categories: chronic pancreatitis, 21 (47%) cases; interstitial fibrosis with or without chronic inflammation, 11 (24%) cases; repair stage of acute pancreatitis, four (9%) cases; severe fatty infiltration, three (7%) cases; chronic inflammation without interstitial fibrosis, two (4%) cases; haemochromatosis, one (2%) case; and undetermined, three (7%) cases. The histological spectrum of chronic pancreatitis was very wide and it was often misdiagnosed. Acinar atrophy, acinar dilation and intralobular fibrosis were diagnostic of chronic pancreatitis. Differential diagnoses include the repair stage of acute pancreatitis, severe fatty infiltration and ...Continue Reading

References

May 1, 1989·American Journal of Clinical Pathology·M ShimizuH Itoh
Jan 1, 1964·American Journal of Clinical Pathology·B CZERNOBILSKY, K W MIKAT

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Citations

May 7, 2004·Journal of Clinical Gastroenterology·Esmeralda C Marginean, Dhanpat Jain
Oct 23, 2012·Digestive Diseases and Sciences·Khalid M KhanHoracio Rodriguez-Rilo
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Lyndon V Hernandez, Marc F Catalano
May 24, 2014·Diabetes Care·Christina EllervikThomas Mandrup-Poulsen
Mar 8, 2016·Lancet·Shounak Majumder, Suresh T Chari
Feb 13, 2015·Pancreas·Gyanprakash A KetwarooSunil G Sheth
Mar 10, 2016·The American Journal of Gastroenterology·Guru TrikudanathanRajeev Attam
Aug 5, 2017·Current Opinion in Gastroenterology·Dennis Yang, Chris E Forsmark
Jul 28, 2001·Archives of Pathology & Laboratory Medicine·D M ProcaW L Frankel
Sep 2, 1999·The Surgical Clinics of North America·P G Lankisch

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