Histological assessment of the sclerotic graft-versus-host response in the humanized RAG2-/-γc-/- mouse model

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Marieke C H HogenesRoel A de Weger

Abstract

Graft-versus-host disease (GVHD) remains a frequently occurring and difficult-to-treat complication in human allogeneic stem cell transplantation. Murine transplantation models are often used to study and understand the complex pathogenesis of GVHD and to explore new treatment strategies. Although GVHD kinetics may differ in murine and human models, adequate models are essential for identification of the crucial factors responsible for the major pathology in GVHD. We present a detailed description of the specific histological features of a graft-versus-host-induced fibrotic response in xenogeneic RAG2(-/-)γc(-/-) mice after total body irradiation and injection with human peripheral blood mononuclear cells. We describe the full morphological features of this reaction, including a detailed analysis of the specific tissue infiltration patterns of the human peripheral blood mononuclear cells. Our data show the development of fibrosis, predominantly near blood vessels, and reveal different cell populations and specific cell migration patterns in the affected organs. The combination of immunohistochemical cell characterization and mRNA expression analysis of both human (donor)- and murine (host)-derived cytokines reveals an interacti...Continue Reading

References

Nov 1, 1995·Immunology Today·M Tary-LehmannP V Lehmann
Sep 1, 1993·The Journal of Infectious Diseases·R M HesseltonJ L Sullivan
Jun 13, 1998·Transplantation·E ContassotP Tiberghien
Apr 20, 2000·The Journal of Clinical Investigation·J L Ferrara
Sep 4, 2001·International Journal of Hematology·H J Deeg
Oct 24, 2002·Blood·Görgün AkpekGeorgia B Vogelsang
Jan 27, 2004·Bone Marrow Transplantation·S S Farag
Mar 4, 2008·The Journal of Allergy and Clinical Immunology·Francesco LiottaFrancesco Annunziato
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu-Waye Chu, Ronald E Gress
Apr 18, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M C HagemeijerR A de Weger
May 22, 2008·European Journal of Immunology·Francesco Dazzi, Federica M Marelli-Berg
Dec 26, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Y ZhenY Zhao
Sep 15, 2009·Blood·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Mar 2, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Julie M WuAllan D Hess
May 12, 2011·Disease Models & Mechanisms·Mark A Schroeder, John F DiPersio

❮ Previous
Next ❯

Citations

Mar 19, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sanja StevanovićJ H Frederik Falkenburg
Jun 3, 2015·Inflammatory Bowel Diseases·Iurii KobozievMatthew B Grisham
Mar 19, 2014·Transplantation Reviews·Marieke HogenesRoel de Weger
Oct 6, 2017·Frontiers in Immunology·Barbara DillingerAlexander Michael Dohnal
Jun 18, 2019·Journal of Immunology Research·Marieke C H HogenesRoel A de Weger
Nov 27, 2020·Journal for Immunotherapy of Cancer·Nahee ParkYong Wha Moon

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.