Histological behavior of the vocal fold after hyaluronic acid injection

Journal of Voice : Official Journal of the Voice Foundation
Paulo Sérgio Lins PerazzoCarmem Lúcia Penteado Lancellotti

Abstract

The vocal fold is formed by tissues with abundant cells surrounded by an extracellular matrix. One of the most important components of the extracellular matrix is hyaluronic acid (HA). This study evaluated the inflammatory response of the vocal folds of rabbits submitted to local injection of Restylane HA. We performed a prospective, experimental, and controlled study in 22 New Zealand rabbits with injection in vocal fold. The 22 adult male rabbits underwent a 0.1-ml injection of Restylane HA in one vocal fold and a 0.1-ml injection of saline solution in the other vocal fold, at random. The animals were then subdivided in two distinct groups. One group was sacrificed after a 1-week follow-up and the other group after 3 months. Slides were then stained with hematoxylin-eosin (HE), Masson's trichrome, and toluidine blue. HA was found microscopically in all specimens of both groups. Using the stain (HE), it was easily distinguished. We have measured the inflammatory reaction by histopathology conducted by a pathologist. An increase in connective tissue was found surrounding the HA, and was always associated with a mild inflammatory response. The extended time of exposure did not increase the intensity of the inflammatory reaction....Continue Reading

References

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Citations

Jun 26, 2013·Annals of Biomedical Engineering·Jeffrey C Wolchok, Patrick A Tresco
Mar 23, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Gabriele MolteniLivio Presutti
Mar 30, 2012·Biomedical Materials·Rebecca S BartlettGlenn D Prestwich
Apr 18, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Agata SzkiełkowskaHenryk Skarżyński
Feb 18, 2014·Journal of Voice : Official Journal of the Voice Foundation·Ashleigh A HaldermanRebecca Chota
Feb 5, 2014·Journal of Voice : Official Journal of the Voice Foundation·Sunil P Verma, Seth H Dailey
Nov 26, 2010·Journal of Voice : Official Journal of the Voice Foundation·Paulo Sérgio Lins PerazzoPaulo Augusto de Lima Pontes
Nov 6, 2010·Journal of Voice : Official Journal of the Voice Foundation·Flavia Coelho de SouzaCarmen Lúcia Penteado Lancellotti
May 15, 2012·Journal of Voice : Official Journal of the Voice Foundation·Rudolf ReiterBrosch Sibylle
Oct 26, 2016·Journal of Voice : Official Journal of the Voice Foundation·Henri TraboulsiAbdul-Latif Hamdan
Oct 17, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ming-Hsun WenChi-Te Wang
Jul 13, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seok Jin HongSeung Hoon Woo
Apr 2, 2014·Journal of Speech, Language, and Hearing Research : JSLHR·Jiska M S CoppoolseSam J Daniel
Mar 28, 2019·Ear, Nose, & Throat Journal·Abdul-Latif Hamdan, Elie Khalifee

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