PMID: 9179746May 1, 1997Paper

Histological changes caused by the rc mutation in chickens

Journal of Comparative Pathology
S Cerruti SolaK M Cheng

Abstract

The rc gene represents a recessive mutation in chickens, known to cause retinal degeneration and blindness, as well as abnormal sarcolemmal membranes of cardiac myocytes associated with reduced choline transport. In this study, the visceral organs from "old" (aged 12 months) and "young" (aged 5 months) homozygous blind (rc/rc), heterozygous (Rc+/rc) and normal (Rc+/Rc+) chickens were examined histologically to investigate whether the primary effect of the mutation was on cellular structure. Homozygous birds showed enlarged thyroids with acidophilic colloids in enlarged and often ruptured follicles, macrovesicular lipid accumulation in the liver, increased numbers of nuclei in the myocardial fibres, hypertrophy of the lobular structure of the medullary portion of the thymus, cloudy swelling of the tubular epithelium of the kidney and slow maturation (in young birds) and degeneration (in old birds) of the gonads. All lesions, except for those of the thymus, were more severe in old than in young birds. Some heterozygous chickens were mildly affected and none of the normal (Rc+/Rc+) birds exhibited these abnormalities.

References

Dec 1, 1989·General and Comparative Endocrinology·S F PangC R Nichols
Jun 1, 1985·Experimental Eye Research·R J Ulshafer, C B Allen
May 1, 1973·Lipids·P J O'DohertyA Kuksis
Nov 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·S L PelechD E Vance
Aug 1, 1984·Experimental Eye Research·R J UlshaferE D Wolf
May 1, 1958·The American Journal of Clinical Nutrition·W H GRIFFITH

❮ Previous
Next ❯

Citations

Nov 5, 1999·Experimental Eye Research·S L Semple-Rowland, K M Cheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.