PMID: 9423218Jan 10, 1998Paper

Histological changes in chronic experimental aneurysms surgically fashioned in sheep

Pathology
W E Stehbens

Abstract

After experimental venous pouch saccular aneurysms were surgically fashioned on common carotid arteries of sheep, the ensuing long term hemodynamic effects on the vessel walls were examined up to seven years postoperatively. The aneurysms became more spherical rather than remaining elongated, enlarging at variable, individual rates. Venous sac changes were similar to phlebosclerosis in human veins with progression to sclerotic walls and loss of conventional mural architecture at most sites. Lipid accumulation, despite low serum cholesterol levels, calcification, intimal tears of variable depth, mural dissection and secondary mural thrombosis, occurred as in human atherosclerosis and indicated this model's potential for studies of such pathological disorders and the pathological effects of enhanced hemodynamic stress.

References

Jul 1, 1975·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·W E Stehbens
Feb 12, 1974·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·W E Stehbens
Nov 1, 1970·Journal of Neurosurgery·G G Ferguson
Nov 1, 1995·Circulation Research·C M DolleryA M Henney
Jan 1, 1993·Connective Tissue Research·W E Stehbens, B J Martin
May 1, 1997·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·William E Stehbens

❮ Previous
Next ❯

Citations

Jan 20, 2004·Medical Hypotheses·W E Stehbens
Aug 25, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Annie MajorSophie Lerouge
Sep 24, 1999·Experimental and Molecular Pathology·W E Stehbens
Mar 27, 2001·Experimental and Molecular Pathology·W E Stehbens
May 25, 2002·Medical Hypotheses·W E Stehbens
Jun 12, 2013·Revista do Colégio Brasileiro de Cirurgiões·Severino Lourenço da SilvaJoão Nicolle Tupiná Nogueira
Feb 9, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andrea M HerrmannJohannes Boltze

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.