PMID: 16536052Mar 16, 2006Paper

Histological changes in the alveolar structure of the rat lung after exposure to hyperoxia

Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia
Mohamed Akram Al-Motabagani

Abstract

Oxygen therapy is an important powerful tool in the management of critically ill patients; however, it carries the hazards of pulmonary toxicity if not properly monitored. The aim of the present study was to evaluate the effect of acute and subacute exposure to normobaric hyperphysiologic concentrations of oxygen (O2) on the alveolar structure of rat lung. Thirty adult male albino rats were used in the present work. They were divided equally into 5 groups. Group I included unexposed rats and was considered a control group, group II included rats exposed to 95% O2 for 24 hours, group III included rats exposed as in group II and were left for recovery in room air for 2 weeks, group IV included rats exposed to 60% O2 for two weeks, and group V included rats exposed as in group IV and then left for recovery in room air for another two weeks. The alveolar structure of the rat lung from all groups was examined by light and transmission electron microscopy. The findings of the present work revealed that exposure to 95% O2 for 24 hours resulted in severe pulmonary congestion with extravasation of red blood cells, oedema and alteration in the alveolar structure, while recovery in room air for 2 weeks did not result in repair of the dist...Continue Reading

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