Histological changes of testes in growth hormone transgenic mice with high plasma level of GH and insulin-like growth factor-1

Folia Histochemica Et Cytobiologica
Katarzyna PiotrowskaMariusz Z Ratajczak

Abstract

Overexpression of growth hormone (GH) leads to increase in insulin-like growth factor-1 (IGF-1) plasma level, stimulation of growth and increase in body size, organomegaly and reduced body fat. The action of GH affects all the organs and transgenic mice that overexpress bovine GH (bGH mice) serve as convenient model to study somatotropic axis. Male mice overexpressing GH are fertile, however, they show reduced overall lifespan as well as reproductive life span. The aim of the study was to evaluate the morphology and expression of androgen receptor (AR) and luteinizing hormone receptor (LHR) of bGH mice testes. The experiment was performed on 6 and 12 month-old bGH male mice and 6 and 12 month-old wild type (WT) littermates (8 animals in each group). The morphology of testes was evaluated on deparaffinized sections stained by the periodic acid-Schiff (PAS) method. Expression of AR and LHR was investigated by immunohistochemistry and diameters of seminiferous tubules (ST) were measured on round cross sections of ST. We noted larger testes in 6-month bGH mice as compared to normal WT littermates. The morpho-logical observations revealed essentially normal structure of Leydig cells, seminiferous epithelium and other morphological s...Continue Reading

Citations

Jul 4, 2020·Animal Science Journal = Nihon Chikusan Gakkaihō·Jiuxiu JiLizeng Guan
Nov 30, 2019·Frontiers in Endocrinology·Emina IpsaKevin N Keane
Nov 8, 2019·Animal Biotechnology·Angang LouLizeng Guan
May 30, 2021·Journal of Endocrinological Investigation·M K YilmazP Kadioglu

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