Histological comparison between predictive value of preoperative 3-T multiparametric MRI and 68 Ga-PSMA PET/CT scan for pathological outcomes at radical prostatectomy and pelvic lymph node dissection for prostate cancer.

BJU International
Anthony FranklinJohn Yaxley

Abstract

To evaluate the ability of preoperative multiparametric magnetic resonance imaging (mpMRI) and a gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA PET/CT) scan to predict pathological outcomes and also identify a group of men with a <5% risk of histological pelvic lymph node metastasis (LNM) at pelvic lymph node dissection (PLND) performed during a robot-assisted laparoscopic radical prostatectomy (RALP) for prostate cancer. We then aimed to compare these results to known risk calculators for LNM, including the Cancer of the Prostate Risk Assessment (CAPRA) score, Memorial Sloan Kettering Cancer Centre (MSKCC) and Briganti nomograms. Between July 2014 and September 2019 only men who had both a preoperative mpMRI and staging 68 Ga-PSMA PET/CT at our institution followed by a RALP with PLND referred to a single specialist uropathology laboratory were considered for inclusion. The data were collected retrospectively prior to February 2019 and in a prospective manner thereafter. A model was built to allocate probabilities of the men with a negative 68 Ga-PSMA PET/CT scan having a <5% risk of histologically LNM at RALP based on the preoperative radiological staging. A total of...Continue Reading

References

Mar 20, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F AbdollahA Briganti
May 23, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olivio F DonatiOguz Akin
Feb 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Christian UprimnyIrene Johanna Virgolini
Aug 5, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nadine WoythalVikas Prasad
Nov 6, 2018·Nuclear Medicine Communications·Emre DemirciAli R Kural
May 16, 2019·Journal of the National Comprehensive Cancer Network : JNCCN·James L MohlerDeborah A Freedman-Cass

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