Histological evaluation of human intrabony periodontal defects treated with an unsintered nanocrystalline hydroxyapatite paste.

Clinical Oral Investigations
Attila HorváthA Sculean

Abstract

The aim of the study was to clinically and histologically evaluate the healing of human intrabony defects treated with open flap surgery (OFD) and application of a new, resorbable, fully synthetic, unsintered, nanocrystalline, phase-pure hydroxyapatite (nano-HA). Six patients, each of them displaying very advanced intrabony defects around teeth scheduled for extraction due to advanced chronic periodontitis and further prosthodontic considerations, were included in the study. Following local anaesthesia, mucoperiosteal flaps were reflected; the granulation tissue was removed, and the roots were meticulously debrided by hand and ultrasonic instruments. A notch was placed at the most apical extent of the calculus present on the root surface or at the most apical part of the defect (if no calculus was present) in order to serve as a reference for the histological evaluation. Following defect fill with nano-HA, the flaps were sutured by means of mattress sutures to allow primary intention healing. At 7 months after regenerative surgery, the teeth were extracted together with some of their surrounding soft and hard tissues and processed for histological analysis. The postoperative healing was uneventful in all cases. At 7 months foll...Continue Reading

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Citations

Jan 6, 2015·Journal of International Society of Preventive & Community Dentistry·Jasuma Jagdish Rai, Thanveer Kalantharakath
Mar 8, 2013·Journal of Materials Science. Materials in Medicine·Sergey V Dorozhkin
Apr 14, 2015·Periodontology 2000·Anton SculeanWilliam V Giannobile
Apr 14, 2015·Periodontology 2000·Anton SculeanAndreas Stavropoulos
Jan 28, 2016·Journal of Applied Oral Science : Revista FOB·Mônica Diuana Calasans-MaiaGutemberg Gomes Alves
Feb 9, 2018·Nanomedicine·Rafał PokrowieckiAgnieszka Mielczarek

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