Histological Evidence of Chronic Mycoplasma genitalium-Induced Cervicitis in HIV-Infected Women: A Retrospective Cohort Study

The Journal of Infectious Diseases
Patricia M DehonChris L McGowin

Abstract

Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in inflammatory syndromes of the female reproductive tract. The objective of this study was to investigate human immunodeficiency virus (HIV)-infected women for an association between M. genitalium and cervicitis, a putative mechanism for enhanced HIV transmission efficiency to an uninfected partner. Using a longitudinal cohort of antiretroviral therapy-adherent New Orleans women, we retrospectively screened for M. genitalium and quantitatively characterized several markers of cervical inflammation, including secreted cytokines and cytological and histological signs of leukocyte infiltration. We observed a high prevalence of M. genitalium (7.4%) among HIV-infected New Orleans women. Chronic M. genitalium infection was associated with increased secretion of proinflammatory cytokines, including interleukin 1β, interleukin 6, and interleukin 8, and marked inflammatory cervical infiltrates in the cervix with enrichment of HIV target cells. Cure of M. genitalium infection resulted in ablation of all signs of inflammation. These findings implicate M. genitalium as an etiologic agent of cervicitis in HIV-infected women, providing a potential mechanism for en...Continue Reading

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Citations

Mar 7, 2018·Sexually Transmitted Diseases·Lao-Tzu Allan-BlitzJeffrey D Klausner
Aug 26, 2017·The Journal of Infectious Diseases·Chris L McGowin, Patricia A Totten
Aug 26, 2017·The Journal of Infectious Diseases·Harold C Wiesenfeld, Lisa E Manhart
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Cameron KleinPeter C Angeletti
May 2, 2020·Cancers·Cameron KleinPeter C Angeletti
Mar 18, 2021·Epidemiologia E Serviços De Saúde : Revista Do Sistema Unico De Saúde Do Brasil·Angélica Espinosa MirandaNewton Sergio de Carvalho
May 20, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Angélica Espinosa MirandaNewton Sergio de Carvalho

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