PMID: 2497429Feb 1, 1989Paper

Histological examination of the cellular reactions around schistosomula of Schistosoma mansoni in the lungs of sublethally irradiated and unirradiated, immune and control rats

Parasitology
D A VignaliM G Taylor

Abstract

Histopathological data on the cellular reactions (foci) around Schistosoma mansoni schistosomula in the lungs of both irradiated (750 rad) and unirradiated, passively immunized and normal rats were consistent with the idea that a significant proportion of immune-mediated attrition in passively immunized rats occurs in the lungs. In unirradiated rats, immune serum elicited an enhanced (i.e. larger) and accelerated (i.e. more rapidly developing) inflammatory cellular infiltration around lung-stage parasites when administered 5 days post-infection, when the parasites were already in the lungs. This demonstrated the antigenicity of lung-stage schistosomula and their potential as targets for immune attack. In irradiated rats, innate immunity was decreased as judged by an increase in the number of worms recovered by portal perfusion, and was accompanied by an overall decreased percentage of trapped parasites compared with unirradiated controls, suggesting that trapping in the lungs is involved in innate, as well as acquired immunity. In contrast to the results in unirradiated rats, passive transfer of immune serum into irradiated recipients did not result in larger lung foci than in the NRS-recipients. However, there was evidence of ...Continue Reading

References

Apr 1, 1979·Experimental Parasitology·S N Chen, R E Howells
May 1, 1986·The American Journal of Tropical Medicine and Hygiene·R OshmanJ E Byram
Nov 1, 1986·The American Journal of Tropical Medicine and Hygiene·P M KnopfD A Dean
Mar 1, 1974·European Journal of Immunology·R E AndersonJ F Miller
Jan 1, 1982·Immunological Reviews·A CapronG Torpier

❮ Previous
Next ❯

Citations

Jan 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·R A WilsonG D Reid
Jul 31, 2004·American Journal of Respiratory Cell and Molecular Biology·J Koenraad van de WeteringJaap J van Hellemond
Jan 1, 1991·Revista Do Instituto De Medicina Tropical De São Paulo·P M CoelhoS E Gerken
Sep 6, 2005·Parasite Immunology·J P HewitsonA P Mountford

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.