Abstract
Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 chronic users of NSAIDs and 61 controls. Each specimen was graded from 0 to 3 for each of the following features: foveolar hyperplasia, smooth muscle fibers, edema, neutrophils, intestinal metaplasia, eosinophils, mononuclear cells, mucosal hemorrhage, atrophy, and Helicobacter pylori. We found that foveolar hyperplasia, considered one of the characteristic features of chemical gastropathy, was absent in 66% of NSAID users. Foveolar hyperplasia was present in 37 NSAID users (34%) and in 10 controls (18%); prominent smooth muscle fibers were found in 51 NSAID users (47%) and 10 of the controls (16%). Concurrent H pylori gastritis obscured the histopathologic changes of NSAID use. All other parameters, including H pylori infection rate (57% v 51%) were similar in NSAID users and controls. We conclude that the histological features characteristic of NSAID users were present only in a subset of patients. No single histo...Continue Reading
References
Feb 1, 1992·Journal of Clinical Pathology·A S TahaR I Russell
Mar 1, 1991·Journal of Gastroenterology and Hepatology·M F Dixon
May 1, 1991·Journal of Gastroenterology and Hepatology·A B Price
Apr 1, 1990·Journal of Clinical Pathology·G M SobalaM F Dixon
Oct 25, 1986·Lancet·M SalmeronR Houdart
Nov 22, 1986·Lancet·H J O'ConnorD Johnston
Mar 1, 1989·Digestive Diseases and Sciences·L G CoelhoM M Walker
Apr 1, 1988·European Journal of Clinical Investigation·G BörschE Reitemeyer
Aug 1, 1988·Gastroenterology·F L LanzaA Rubin
Jun 1, 1988·Digestive Diseases and Sciences·C W PettrossL A Laine
May 1, 1987·Scandinavian Journal of Gastroenterology·T KarttunenO Räsänen
May 1, 1986·Journal of Clinical Pathology·M F DixonD Johnston
May 1, 1986·Journal of Clinical Pathology·H J O'ConnorA T Axon
Dec 1, 1985·Gut·M I FilipeR Zeegen
May 1, 1974·Annals of Surgery·T Drapanas, M Bethea
Nov 1, 1983·World Journal of Surgery·E P DewarD Johnston
Jun 1, 1983·Gut·R C Heading
Jul 17, 1980·The New England Journal of Medicine·F L LanzaR S Nelson
Mar 1, 1994·Human Pathology·R M GentaD Y Graham
May 1, 1994·Gastrointestinal Endoscopy·R M Genta, D Y Graham
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·R M Genta, D Y Graham
Jul 6, 1994·JAMA : the Journal of the American Medical Association
Mar 1, 1993·The Journal of International Medical Research·A A al-QuorainI al-Habdan
Oct 1, 1993·Histopathology·C M QuinnA B Price
Jul 1, 1993·Gastroenterology·D Y Graham, M F Go
Citations
May 3, 2000·Alimentary Pharmacology & Therapeutics·G DortaD Armstrong
Jun 29, 2001·Journal of Clinical Pathology·M FrezzaM Melato
May 3, 2002·Journal of Clinical Pathology·M VoutilainenP Sipponen
Apr 19, 2011·Human Pathology·Robert M Genta
Jun 1, 2010·Surgical Pathology Clinics·Ilyssa O GordonAmy E Noffsinger
Jan 6, 2007·Histopathology·A Srivastava, G Y Lauwers
Aug 30, 2012·Alimentary Pharmacology & Therapeutics·I MaguilnikR M Genta
Aug 31, 2006·Seminars in Diagnostic Pathology·Robert M Genta
Jul 27, 2010·Human Pathology·Robert M GentaSmita Suterwala
Jan 24, 2007·Helicobacter·A C de VriesE J Kuipers
Jan 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rhonda K Yantiss
Jun 5, 2016·BMC Gastroenterology·Thiago Gagliano-JucáGilberto De Nucci
Apr 4, 2017·Histopathology·James R Conner, Richard Kirsch
Feb 7, 2001·Gastroenterology Clinics of North America·M S Cappell, J R Schein
Jun 13, 1998·The American Journal of Gastroenterology·A LászlóS Shapiro
Jun 18, 2005·World Journal of Gastroenterology : WJG·Bin DongJi-You Li
Aug 9, 2001·Histopathology·G Y LauwersP S Kubilis
Mar 3, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Barbara J McKenna, Henry D Appelman
Apr 27, 2018·Helicobacter·Sadaf SaghierSimon S Rabinowitz
Sep 18, 2008·Journal of Clinical Gastroenterology·Helena T J I De LeestBen A C Dijkmans
Jul 9, 1998·Pathology Oncology Research : POR·G Cserni
Feb 13, 2003·Pathology Oncology Research : POR·Julián Arista-NasrBraulio Martinez
Nov 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Dinesh S PashankarFrank A Mitros
Apr 26, 2006·Scandinavian Journal of Gastroenterology·Meera LadwaIngvar Bjarnason
Jun 28, 2019·Archives of Pathology & Laboratory Medicine·David R MartinDouglas P Clark
Jan 11, 2005·The Journal of Biological Chemistry·Michael H PillingerSteven B Abramson
Sep 27, 2018·Virchows Archiv : an International Journal of Pathology·Hala El-ZimaityRobert Riddell
Feb 19, 2000·The American Journal of Surgical Pathology·M RuggeH Watanabe
Nov 11, 1999·Annals of Diagnostic Pathology·M M Haber, I Lopez
Sep 30, 2021·Alimentary Pharmacology & Therapeutics·Robert M GentaAmnon Sonnenberg
Sep 29, 2011·Gastrointestinal Endoscopy Clinics of North America·Joanna A Gibson, Robert D Odze