Histological features do not define NSAID-induced gastritis

Human Pathology
H M El-ZimaityD Y Graham

Abstract

Nonsteroidal anti-inflammatory drug (NSAID) use is a common cause of peptic ulcer. This study investigated the nature, frequency, and topographic distribution of histological abnormalities of the gastric mucosa associated with chronic NSAID use. A set of 3 to 11 mapped gastric biopsy specimens were obtained from 108 chronic users of NSAIDs and 61 controls. Each specimen was graded from 0 to 3 for each of the following features: foveolar hyperplasia, smooth muscle fibers, edema, neutrophils, intestinal metaplasia, eosinophils, mononuclear cells, mucosal hemorrhage, atrophy, and Helicobacter pylori. We found that foveolar hyperplasia, considered one of the characteristic features of chemical gastropathy, was absent in 66% of NSAID users. Foveolar hyperplasia was present in 37 NSAID users (34%) and in 10 controls (18%); prominent smooth muscle fibers were found in 51 NSAID users (47%) and 10 of the controls (16%). Concurrent H pylori gastritis obscured the histopathologic changes of NSAID use. All other parameters, including H pylori infection rate (57% v 51%) were similar in NSAID users and controls. We conclude that the histological features characteristic of NSAID users were present only in a subset of patients. No single histo...Continue Reading

References

Mar 1, 1991·Journal of Gastroenterology and Hepatology·M F Dixon
May 1, 1991·Journal of Gastroenterology and Hepatology·A B Price
Apr 1, 1990·Journal of Clinical Pathology·G M SobalaM F Dixon
Oct 25, 1986·Lancet·M SalmeronR Houdart
Mar 1, 1989·Digestive Diseases and Sciences·L G CoelhoM M Walker
May 1, 1987·Scandinavian Journal of Gastroenterology·T KarttunenO Räsänen
May 1, 1986·Journal of Clinical Pathology·M F DixonD Johnston
May 1, 1986·Journal of Clinical Pathology·H J O'ConnorA T Axon
May 1, 1974·Annals of Surgery·T Drapanas, M Bethea
Jun 1, 1983·Gut·R C Heading
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·R M Genta, D Y Graham
Oct 1, 1993·Histopathology·C M QuinnA B Price
Jul 1, 1993·Gastroenterology·D Y Graham, M F Go

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Citations

May 3, 2002·Journal of Clinical Pathology·M VoutilainenP Sipponen
Jun 1, 2010·Surgical Pathology Clinics·Ilyssa O GordonAmy E Noffsinger
Jan 6, 2007·Histopathology·A Srivastava, G Y Lauwers
Aug 30, 2012·Alimentary Pharmacology & Therapeutics·I MaguilnikR M Genta
Aug 31, 2006·Seminars in Diagnostic Pathology·Robert M Genta
Jan 7, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rhonda K Yantiss
Apr 4, 2017·Histopathology·James R Conner, Richard Kirsch
Feb 7, 2001·Gastroenterology Clinics of North America·M S Cappell, J R Schein
Mar 3, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Barbara J McKenna, Henry D Appelman
Jul 9, 1998·Pathology Oncology Research : POR·G Cserni
Nov 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Dinesh S PashankarFrank A Mitros
Apr 26, 2006·Scandinavian Journal of Gastroenterology·Meera LadwaIngvar Bjarnason
Jun 28, 2019·Archives of Pathology & Laboratory Medicine·David R MartinDouglas P Clark
Jan 11, 2005·The Journal of Biological Chemistry·Michael H PillingerSteven B Abramson
Sep 27, 2018·Virchows Archiv : an International Journal of Pathology·Hala El-ZimaityRobert Riddell
Feb 19, 2000·The American Journal of Surgical Pathology·M RuggeH Watanabe
Nov 11, 1999·Annals of Diagnostic Pathology·M M Haber, I Lopez
Sep 30, 2021·Alimentary Pharmacology & Therapeutics·Robert M GentaAmnon Sonnenberg
Sep 29, 2011·Gastrointestinal Endoscopy Clinics of North America·Joanna A Gibson, Robert D Odze

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