Abstract
Clinical presentation, maximal aortic diameter (Dmax), and growth rate are considered important clinical characteristics of the abdominal aortic aneurysm (AAA). Histologically, AAA is characterized by pathological changes of the media. In the present study, we investigated whether and how the histological features of AAA were related to clinical characteristics. Clinical characteristics and anterior aneurysm wall biopsies were collected prospectively. Histological characteristics were determined by immunohistochemistry and morphometric analysis. Thirty-nine consecutive patients with elective or emergency aneurysm repair were included. AAA was located infra- or juxtarenal in 77% and 23%, respectively. Mean maximal aortic diameter was 67 mm with a mean growth rate of 6 mm/year. The histological features included a low elastin content, distorted elastin configuration, high collagen content, diminutive number of smooth muscle cells, and a high number of medial microvessels and inflammatory cells dominated by T cells. However, no intra- or interrelationship between histological and clinical characteristics was present. In particular, Dmax and clinical presentation were not related to media thickness or inflammatory cell count. We co...Continue Reading
References
Sep 1, 1990·Circulation·S AnidjarJ B Michel
Dec 1, 1987·Journal of Vascular Surgery·S MenashiJ T Powell
Jun 12, 2004·Journal of Vascular Surgery·Mark F FillingerEva M Rzucidlo
May 12, 2005·Immunology·Nerys D ForesterSimon R Carding
Mar 2, 2006·The American Journal of Pathology·Ziad TouatJean-Baptiste Michel
Dec 22, 2006·Annals of the New York Academy of Sciences·Edward ChokeMatthew M Thompson
Citations
May 25, 2012·Biomechanics and Modeling in Mechanobiology·Ming-Jay ChowYanhang Zhang
Mar 6, 2013·Cardiovascular Research·Magnus BäckGiuseppina Caligiuri
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Petra A PrinsUchechukwu K Sampson
Dec 21, 2013·PloS One·Ming-Jay ChowYanhang Zhang
Jan 28, 2014·PloS One·Petra A PrinsUchechukwu K Sampson
Dec 3, 2014·Journal of Vascular Surgery·Christian ReepsMichael W Gee
Jan 5, 2016·Acta histochemica·Evanthia MourmouraAspasia Tsezou
Jan 8, 2016·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Shana R WatsonSusan M Lessner
May 9, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Kamil NovakJiri Bursa
Dec 1, 2009·Journal of Vascular Surgery·Lambert SpeelmanMichael H Jacobs
Aug 17, 2011·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B PulinxW K W H Wodzig
Aug 8, 2014·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Philipp ErhartAlexander Hyhlik-Dürr
Dec 31, 2014·Medical & Biological Engineering & Computing·Eleni MetaxaYannis Papaharilaou
Jun 8, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Nikesh DattaniMatthew J Bown
Nov 2, 2012·Expert Review of Cardiovascular Therapy·Xing Li WangAndrew Zalewski
Oct 18, 2019·Frontiers in Endocrinology·Emanuel Bottasso
Jun 24, 2009·Nature Reviews. Cardiology·Femke A M V I HellenthalGeert Willem H Schurink
Nov 19, 2016·Journal of the Belgian Society of Radiology·Alain Nchimi
Jun 18, 2021·Frontiers in Cardiovascular Medicine·Hsin-Ying LuChun-Che Shih