Histological features of layers and sublayers in cortical visual areas V1 and V2 of chimpanzees, macaque monkeys, and humans

Eye and Brain
Pooja BalaramJon H Kaas

Abstract

The layers and sublayers of primary visual cortex, or V1, in primates are easily distinguishable compared to those in other cortical areas, and are especially distinct in anthropoid primates - monkeys, apes, and humans - where they also vary in histological appearance. This variation in primate-specific specialization has led to a longstanding confusion over the identity of layer 4 and its proposed sublayers in V1. As the application of different histological markers relate to the issue of defining and identifying layers and sublayers, we applied four traditional and four more recent histological markers to brain sections of V1 and adjoining secondary visual cortex (V2) in macaque monkeys, chimpanzees, and humans in order to compare identifiable layers and sublayers in both cortical areas across these species. The use of Nissl, neuronal nuclear antigen (NeuN), Gallyas myelin, cytochrome oxidase (CO), acetylcholinesterase (AChE), nonphosphorylated neurofilament H (SMI-32), parvalbumin (PV), and vesicular glutamate transporter 2 (VGLUT2) preparations support the conclusion that the most popular scheme of V1 lamination, that of Brodmann, misidentifies sublayers of layer 3 (3Bβ and 3C) as sublayers of layer 4 (4A and 4B), and that ...Continue Reading

Citations

Jan 6, 2017·Journal of Neurophysiology·Benjamin SchollJeffrey Padberg
Jul 1, 2017·Annual Review of Neuroscience·Ed S LeinZoltán Molnár
May 20, 2021·Journal of Neurophysiology·Christopher VersteegLee E Miller
Sep 16, 2021·Annual Review of Vision Science·Anita A Disney
Nov 16, 2021·NeuroImage·Xingfeng ShaoDanny J J Wang

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