Histological grading of therapy induced regression in squamous cell carcinomas of the oral cavity. A morphological and immunohistochemical study

Pathology, Research and Practice
O BraunN Gritzmann

Abstract

Squamous cell carcinomas in the oral cavity and the oropharynx were diagnosed in 84 patients. After verification by biopsy, 79 of these patients were treated preoperatively with mitomycin C and 5-fluro-uracil, radiated and operated 3-5 weeks later. The effectiveness of adjuvant preoperative radio-chemotherapy was evaluated histologically. Serial sections of the entire tumor specimen were investigated and the percentage of vital cancerous tissue in the total tumor area was assessed. Regression was classified into four grades. Grades I and II were regarded as good response to adjuvant preoperative radio-chemotherapy, while grades III and IV stood for bad or no response. Morphologically questionable residual tumor infiltrates could be clarified by immunohistochemical methods with antibodies against vimentin, desmin and Lu-5. The histological assessment of the regression grade of operated tumor specimens allows a clinically relevant, morphologically exact and reproducible evaluation of the effect of preoperative radiochemotherapy.

References

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·W W FrankeC Stähli
Oct 1, 1988·Cancer·L OlaszA Horváth
Apr 1, 1985·Archives of Otolaryngology·M J KaplanR W Cantrell
Nov 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M Hsu, L Raine
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·G ThomasS Fine
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·M Salzer-KuntschikR Sigmund

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