Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review

Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
Ling NieQin Huang

Abstract

Carcinosarcoma is a rare malignant neoplasm, consisting of both epithelial and mesenchymal component. Primary gastric carcinosarcoma is rare and poorly understood. We reported clinicopathologic features of 4 cases and analysis of 76 cases published in the literature. Clinical symptoms were nonspecific with epigastric pain, weight loss, and melena, as the most common complaints. The prognosis of patients was dismal with high mortality. The tumor commonly occurred in the upper stomach in Chinese patients, whereas, it was more prevalent at the lower stomach in Japanese and other populations. The two malignant components of this rare cancer showed considerable histological heterogeneity with a wide range of differentiation. We propose that carcinosarcomas be divided in two main subtypes: conventional carcinosarcoma and carcinosarcoma, not-otherwise-specified (NOS). Such distinction may provide useful information for targeted treatment of various sarcomatous components of this tumor. Immunohistochemistry should be routinely applied in the diagnosis of this rare tumor.

Citations

Dec 25, 2019·Case Reports in Pathology·Giovanni CentonzeMassimo Milione
Jun 11, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Eyal AviviHaim Shirin
Jan 22, 2020·Surgical Case Reports·Kenichiro FurukawaYasuhiro Tsubosa
Sep 26, 2020·Journal of Digestive Diseases·Qin HuangXiao Ping Zou
Dec 30, 2020·The Journal of International Medical Research·Zhishang ZhangYangkun Wang

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Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.