Histological, histochemical and ultrastructural study of slipped capital femoral epiphysis

Journal of Children's Orthopaedics
I TresoldiE Ippolito

Abstract

The purpose of our study was to investigate the histological, histochemical and ultrastructural aspects of the proximal femoral growth plate in slipped capital femoral epiphysis (SCFE). Eight core biopsies of the proximal femoral growth plate were performed during in situ epiphysiodesis in patients with SCFE that was at the pre-slipping stage in two cases and at the mild slipping stage (Southwick angle < 30°) in six cases. After fixation, the specimens were processed for either histological or histochemical or ultrastructural studies. The proximal femoral growth plate was thicker than normal in the SCFE cases, and the 3:1 ratio between the thickness of the resting zone and the other zones of the plate was reversed. Chondrocytes of the proliferating, maturation, hypertrophic and degenerating zones were arranged in large clusters rather than in columns, which were separated by loose fibrillary septae that appeared moderately alcian blue positive and metachromatic. The collagen fibrils of the longitudinal septae were uniformly thin, measuring about 200 Å, whereas in the normal plate collagen fibrils were in the range of 300 to 1200 Å in thickness. Chondrocytes were elongated and smaller than normal, with a dark cytoplasm. In the d...Continue Reading

References

Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E IppolitoD Perugia
Jun 17, 2005·Journal of Pediatric Orthopedics·Mark J AdamczykWalter E Horton
May 8, 2009·Folia Histochemica Et Cytobiologica·Franciszek BurdanJarosław Dudka
May 7, 2010·Acta Orthopaedica·Francesco FalcigliaVincenzo Guzzanti

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Citations

May 23, 2017·Journal of Children's Orthopaedics·R Krauspe, S Weinstein
Jun 12, 2018·Journal of Pediatric Orthopedics·Daniel A MaranhoEduardo N Novais
Apr 7, 2020·Journal of Pediatric Orthopedics·Manuel Montañez-AlvarezMarisa Ramírez-Ruiz
Feb 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Richard T EppersonPeter Stevens
Jul 31, 2021·JBJS Case Connector·Matthew RosenKristin Harmon
Jul 10, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ronald Vincent Perrone, John Leicester Williams

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Methods Mentioned

BETA
biopsies
biopsy

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