Histological inflammatory changes after surgery at the epithelium of the distal esophagus in patients with Barrett's esophagus: a comparison of two surgical procedures

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
Italo BraghettoOwen Korn

Abstract

There are many reports concerning the surgical treatment of patients with Barrett's esophagus, but very few focus on histological changes of inflammatory cells in squamous and columnar epithelium before and late after classic antireflux or acid suppression-duodenal diversion surgery. We evaluate the impact of these procedures in the presence of intestinal metaplasia, dysplasia and Helicobacter pylori in the columnar epithelium. Two groups of patients were studied, 37 subjected to classic antireflux and 96 to acid suppression-duodenal diversion operations. They were subjected to endoscopic and histological studies before and at 1, 3 and more than 5 years after surgery. Manometric evaluations and 24 h pH monitoring were performed before and at 1 year after surgery. The presence of inflammatory cells at both the squamous and columnar epithelium was significantly higher at the late follow up in patients subjected to classic antireflux surgery compared with patients subjected to acid suppression-duodenal diversion operations (P < 0.02 and P < 0.001, respectively). Intestinal metaplasia, present in 100% of patients before surgery, had decreased significantly at 3 years after surgery in patients subjected to acid suppression-duodenal ...Continue Reading

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Citations

Sep 12, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hugo BonattiRonald A Hinder
Jul 2, 2005·Gastrointestinal Endoscopy Clinics of North America·Ronald W Yeh, George Triadafilopoulos
May 4, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Attila CsendesOwen Korn
May 30, 2015·Gastroenterology Clinics of North America·Christian G Peyre, Thomas J Watson
Jan 6, 2006·European Journal of Gastroenterology & Hepatology·Spiros N SgourosApostolos Mantides
Aug 29, 2019·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Italo Braghetto, Attila Csendes
May 13, 2017·Head & Neck·David J WellensteinGuido B van den Broek

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