Histological outcome for chronic hepatitis B patients treated with entecavir vs lamivudine-based therapy

World Journal of Gastroenterology : WJG
Jia-Li WangWen-Hong Zhang

Abstract

To compare the histological outcome of chronic hepatitis B (CHB) patients treated with entecavir (ETV) or lamivudine (LAM)-based therapy. We conducted a retrospective analysis of data from 42 CHB patients with advanced fibrosis (baseline Ishak score ≥ 2) or cirrhosis who were treated with ETV or LAM-based therapy in Beilun People's Hospital, Ningbo between January 2005 and May 2012. The patients enrolled were more than 16 years of age and underwent a minimum of 12 mo of antiviral therapy. We collected data on the baseline characteristics of each patient and obtained paired liver biopsies pre- and post-treatment. The Knodell scoring system and Ishak fibrosis scores were used to evaluate each example. An improvement or worsening of necroinflammation was defined as ≥ 2-point change in the Knodell inflammatory score. The progression or regression of fibrosis was defined as ≥ 1-point change in the Ishak fibrosis score. The continuous variables were compared using t-test or Mann-Whitney test, and the binary variables were compared using χ(2) test or Fisher's exact test. The results of paired liver biopsies were compared with a Wilcoxon signed rank test. Nineteen patients were treated with ETV and 23 patients were treated with LAM the...Continue Reading

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Citations

May 25, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Gautam Ray
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Nov 12, 2021·Chinese Medical Journal·Qian ZhangHong Ren

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