Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina

Brain Research
Kenji SakamotoKunio Ishii

Abstract

Brief ischemia was reported to protect various cells against injury induced by subsequent ischemia-reperfusion, and this phenomenon is known as ischemic preconditioning. The aims of the present study were to clarify whether early ischemic preconditioning could be observed in the rat retina by histological examination. Male Sprague-Dawley rats were subjected to 60 min of retinal ischemia by raising intraocular pressure to 130 mm Hg. Ischemic preconditioning was achieved by applying 5 min of ischemia 5-60 min before 60 min of ischemia. Additional groups of rats received 10 mg/kg 8-phenyltheophiline and 4.5 mg/kg 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), adenosine A1 receptor antagonists, 5 mg/kg 5-hydroxydecanoate and 1 mg/kg glibenclamide, ATP-sensitive K+ channel blockers, or 2.5 mg/kg chelerythrine and 0.1 mg/kg bisindolylmaleimide I, protein kinase C inhibitors, 15 or 30 min before preconditioning. In the non-preconditioned group, cell loss in the ganglion cell layer and thinning of the inner plexiform and inner nuclear layer were observed 7 days after 60 min of ischemia. Five minutes of preconditioning ischemia 20-40 min before 60 min of sustained ischemia completely prevented the retinal tissue damage induced by the susta...Continue Reading

References

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Citations

Jul 1, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kenji SakamotoKunio Ishii
Jan 31, 2009·Acta Histochemica Et Cytochemica·Chen DanLuo Xue-Gang
Apr 14, 2010·International Journal of Molecular Sciences·Krisztina SzabadfiTamas Atlasz
Jan 15, 2014·Neurochemistry International·Lisa Nivison-SmithMichael Kalloniatis
Jun 22, 2011·Progress in Retinal and Eye Research·Antje WurmAndreas Bringmann
Feb 24, 2009·Trends in Neurosciences·Gary D HousleyAndreas Reichenbach
Feb 27, 2013·Glia·Andreas Reichenbach, Andreas Bringmann
Nov 23, 2006·Brain Research Bulletin·Ulrika LönngrenFinn Hallböök
Nov 24, 2011·Progress in Retinal and Eye Research·Christian Caprara, Christian Grimm
Mar 4, 2010·Journal of Pharmacological Sciences·Kenji SakamotoKunio Ishii
Nov 16, 2005·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Mitrofanis PavlidisSolon Thanos
Sep 17, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Andreas Bringmann, Peter Wiedemann
Jun 5, 2013·Molecular Medicine Reports·Yi-Sheng ZhongYi-Hua Zhu
Jul 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naoto OgawaKunio Ishii
Mar 18, 2021·Cellular and Molecular Neurobiology·D Pereira-FigueiredoK C Calaza
May 1, 2021·International Journal of Molecular Sciences·Agnieszka KamińskaMario Damiano Toro

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