Histological response to injected gluteraldehyde cross-linked bovine collagen based implant in a rat model

BMC Urology
Murat AlkanNebil Büyükpamukçu

Abstract

The aim of present study is to investigate the short and long term histopathological alterations caused by submucosal injection of gluteraldehyde cross-linked bovine collagen based on an experimental rat model. Sixty Sprague-Dawley rats were assigned into two groups as group I and II each containing 30 rats. 0.1 ml of saline solution and 0.1 ml of gluteraldehyde cross-linked bovine collagen were injected into the submucosa of bladder of first (control) and second groups, respectively. Both group I and II were further subdivided into 3 other groups as Group IA, IB, IC and Group IIA, IIB, IIC according to the sacrification period. Group IA and IIA, IB and IIB, IC and IIC rats (10 rats for each group) were sacrificed 3, 6, and 12 months after surgical procedure, respectively. Two slides prepared from injection site of the bladder were evaluated completely for each rat by being unaware of the groups and at random by two independent senior pathologists to determine the fibroblast invasion, collagen formation, capillary ingrowth and inflammatory reaction. Additionally, randomized brain sections from each rat were also examined to detect migration of the injection material. The measurements were made using an ocular micrometer at x10 ...Continue Reading

References

Jan 1, 1992·British Journal of Urology·P A Dewan
Dec 1, 1986·British Journal of Urology·B O'Donnell, P Puri
Jan 1, 1985·Human Pathology·W D TravisJ L Abraham
Jun 22, 1984·JAMA : the Journal of the American Medical Association·A A MaliziaW J Utz
Jan 1, 1993·European Urology·I A AaronsonP D Garen
Jan 15, 2000·Scandinavian Journal of Urology and Nephrology·A StenbergG Läckgren

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Citations

May 4, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fatima TokhmafshanIndra R Gupta

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