PMID: 19146003Jan 17, 2009Paper

Histological study of expanded polytetrafluoroethylene (Gore-Tex) implanted in the human nose

Rhinology
Chan Hum Park

Abstract

In rhinoplasty, various materials are used for nasal augmentation. Among these, expanded polytetrafluoroethylene (Gore-Tex) is commonly used because of its supposed high biocompatibility. However, most studies regarding histological changes associated with its implantation have been carried out in animal models, and very few data are available from long-term human studies. We used light and electron microscopy to investigate the histological changes associated with expanded polytetrafluoroethylene in nasal augmentation in 30 patients. Histologically, connective tissue ingrowth was observed in all specimens. However, the degree of foreign body reaction and collagen deposition varied from specimen to specimen and had no apparent relationship with duration. Neovascularization was observed in specimens with durations longer than 12 months, and degenerative calcification was observed in a 36-month-duration specimen. Unlike the findings in previous reports, differences among individual responses, degenerative changes, and partially calcified lesions were observed in the expanded polytetrafluoroethylene. Based on this study, expanded polytetrafluoroethylene is a biocompatible material, but further long-term studies are necessary to ad...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.