Histological validation of calcifications in the human hippocampus as seen on computed tomography

PloS One
Melissa E M PetersPim A de Jong

Abstract

Calcifications within the hippocampus were recently described for the first time on computed tomography (CT). These calcifications appeared in patients older than 50 years, the prevalence increases with age and they may be associated with cognitive decline. The aim of this study was to determine the histological basis (the presence, severity and location) of these CT-detected hippocampal calcifications of post-mortem brains. CT scans of seven post-mortem brains were scored for the presence and severity (mild, moderate, severe) of hippocampal calcification. After this, samples from nine hippocampi (bilateral in two brains, unilateral in five brains) were stained with hematoxylin and eosin (HE) to indicate the cytoarchitecture, with Elastica van Gieson to analyse the elastic connective tissue of the vessel walls and with von Kossa for detection of calcium. In four brains (six hippocampi), calcifications were both found on CT and in corresponding histology. In three brains (three hippocampi), calcifications were absent on CT and corresponding histology. In histology, mild calcifications were located in the tail and severe calcifications involved the tail, body and sometimes the head of the hippocampus. The calcifications co-locali...Continue Reading

References

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Citations

Dec 11, 2020·Neurology. Clinical Practice·Melissa E M PetersPim A de Jong
Aug 21, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ralf SchoberMax Holzer
Sep 26, 2020·Journal of the American College of Cardiology·Jonas W BartstraAnnemarie M den Harder

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