Histological verification of atherosclerosis due to bends and bifurcations in carotid arteries predicted by hemodynamic model

Jornal Vascular Brasileiro
Rajani Singh, Richard Shane Tubbs

Abstract

Tortuosity and bifurcations in carotid arteries alter the blood flow, causing atherosclerosis. The aim of the present study is to analyze the effect of variant vascular anatomy in the cervical region on development of atherosclerosis by microanatomical examination. The effect of blood flow at anomalous bends and bifurcations was observed in right carotid arteries of a seventy year old female cadaver. Fifteen histological slides were prepared from the carotid arteries and interpreted to verify predictions of atherosclerosis. The model predicts atherosclerosis at bends, bifurcations and large aperture arteries. Microanatomical examination revealed presence of atherosclerosis of varying thickness at the bends and bifurcation in the right carotid arteries, as predicted. Atherosclerosis was also detected in the straight part of the wider common carotid artery. No atherosclerosis was observed in the contralateral carotid arteries. The variant carotid vascular anatomy consisting of bends, bifurcations and wider arteries revealed that the shear stress and velocity of blood flow are reduced at these anomalous sites. Anatomical anomalies such as bends and branching in the carotid arteries alter the irrigation pattern and generate biomech...Continue Reading

References

Apr 1, 1989·Archives of Otolaryngology--head & Neck Surgery·E RicciardelliA N Schwartz
Sep 13, 1969·Nature·C G CaroR C Schroter
Feb 1, 1981·American Journal of Surgery·D RosenthalD McClusky
Jan 14, 1999·The New England Journal of Medicine·R Ross
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
Sep 9, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·J P Cooke
Aug 17, 2001·Current Opinion in Lipidology·S KinlayP Ganz
Apr 24, 2004·Stroke; a Journal of Cerebral Circulation·Randall T HigashidaUNKNOWN Therapeutic Neuroradiology and the Society of Interventional Radiology
Jul 20, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zuhal OzgurTomris Ozgur
Sep 17, 2009·Angiology·Ricardo BeigelmanJosé Milei
Jun 10, 2011·F1000 Medicine Reports·Christina M WarboysPaul C Evans
Jul 31, 2012·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Djordje RadakPredrag Gajin

❮ Previous
Next ❯

Citations

Oct 16, 2019·Surgical and Radiologic Anatomy : SRA·Raj Kumar, Rajani Singh

❮ Previous
Next ❯

Methods Mentioned

BETA
dissecting

Software Mentioned

Future Winjoe

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Craniofacial Surgery
Rajani Singh, Richard Shane Tubbs
Eastern Mediterranean Health Journal = La Revue De Santé De La Méditerranée Orientale = Al-Majallah Al-ṣiḥḥīyah Li-sharq Al-mutawassiṭ
M A Bakheit, F M Al Gahatani
© 2022 Meta ULC. All rights reserved