PMID: 9546260Apr 18, 1998Paper

Histology and histomorphometry of ethmoid bone in chronic rhinosinusitis

The Laryngoscope
D W KennedyD C Lanza

Abstract

Mucosal changes have been well described in chronic sinusitis, yet little is known about the underlying bone, despite clinical and experimental evidence suggesting that bone may be involved in chronic sinusitis. Techniques of undecalcified bone analysis were used for detailed histologic examination of ethmoid bone in chronic sinusitis compared with controls. Bone synthesis, resorption, and inflammatory cell presence were specifically assessed. Additionally, histomorphometry techniques were used to determine ethmoid bone physiology in individuals undergoing surgery for chronic sinusitis. Overall, individuals undergoing surgery for chronic sinusitis were found to have evidence of marked acceleration in bone physiology with histologic changes including new bone formation, fibrosis, and presence of inflammatory cells. These findings are compared with osteomyelitis in long bone and the jaw. The suggestion that underlying bone may serve as a catalyst for chronic sinusitis is supported and implications for therapy are discussed.

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Citations

Mar 15, 2002·Current Allergy and Asthma Reports·T D Anderson, D W Kennedy
Feb 9, 2011·Current Allergy and Asthma Reports·Vijay R Ramakrishnan, David W Kennedy
Jun 1, 2001·Current Infectious Disease Reports·James A. Hadley
Mar 28, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ward J M VidelerWytske J Fokkens
Sep 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Seok Hyun ChoKyung Rae Kim
Aug 2, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Chan-Soon ParkSoo-Yeon Kim
Apr 6, 2004·Otolaryngologic Clinics of North America·Mark A ZacharekKaren J Fong
Sep 6, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Michael S BenningerHoward Levine
Feb 19, 2003·Auris, Nasus, Larynx·Takashi IshinoKatsuhiro Hirakawa
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mark S La Shell, Michael S Tankersley
Jul 13, 2007·The Journal of Laryngology and Otology·P M Moreno, D H Meseguer
Dec 29, 2000·The Laryngoscope·J R PerloffD W Kennedy
Nov 20, 2002·The Laryngoscope·Ayesha N KhalidDavid W Kennedy
Sep 30, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·James N Palmer, David W Kennedy
Dec 5, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Mark D Rizzi, Ken Kazahaya
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Kathleen T Montone
Sep 23, 2008·Ophthalmic Plastic and Reconstructive Surgery·James Chris FlemingZeynel A Karcioglu
Nov 7, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Laila Mohammed Telmesani, Mohamed Al-Shawarby
Feb 23, 2013·Expert Review of Anti-infective Therapy·R Peter Manes, Pete S Batra
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Dec 22, 2015·The American Journal of Pathology·Stephen L BallAndrew J Fisher
Jul 22, 1998·The American Journal of the Medical Sciences·R R Orlandi, D W Kennedy
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Nov 10, 2015·World Neurosurgery·Mehdi Yahia-CherifOlivier De Witte
Jun 8, 2010·Otolaryngologic Clinics of North America·John M Lee, Alexander G Chiu
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Dec 6, 2005·Otolaryngologic Clinics of North America·Alexander G Chiu
Jun 8, 2006·Otolaryngologic Clinics of North America·Noam A Cohen, David W Kennedy
Nov 7, 2006·American Journal of Otolaryngology·Nithin D Adappa, James M Coticchia
Oct 27, 2011·International Forum of Allergy & Rhinology·Naveen D BhandarkarTimothy L Smith
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Dec 7, 2011·International Forum of Allergy & Rhinology·Yahya Al BadaaiMark Samaha
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Jan 23, 2014·International Forum of Allergy & Rhinology·Kornkiat SnidvongsRichard J Harvey
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Jan 16, 2009·American Journal of Otolaryngology·Michael W CriddleJames Coticchia
Feb 28, 2002·Expert Opinion on Pharmacotherapy·Farhan TaghizadehJ David Osguthorpe

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