Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease occasionally involving the conjunctiva, sclera or cornea. The immunopathology of the active epibulbar lesions has not been studied in detail. Conjunctival biopsies from 11 SLE patients with active epibulbar lesions and from 12 age-matched individuals undergoing cataract surgery were analysed by light microscopy, immunofluorescence and immunoperoxidase techniques. SLE patients presented with scleritis (3 cases), peripheral ulcerative keratitis (5 cases) or progressive cicatrising conjunctivitis (5 cases). Histologically, SLE specimens showed moderate subepithelial and perivascular mononuclear cell infiltration or granuloma formation in the substantia propria, and squamous metaplasia; thrombosis was not seen. Immunoreactant deposition was present at the epithelial basement membrane in 4 of 5 cases with cicatrising conjunctivitis. Vascular immunodeposits wer detected in 4 cases. The epithelium showed increased T helper cells (CD4+), granulocytes and natural killer cells (CD67+), dendritic cells (CD1+), and an increase in HLA-DR expression compared with normal tissue. In the substantia propria, B cells (CD22+), macrophages (CD14+), dendritic cells, activated T cells (CD25+...Continue Reading
References
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T SakaneI Green
Oct 11, 1979·The New England Journal of Medicine·K B Miller, R S Schwartz
Sep 1, 1977·Archives of Ophthalmology·D GoldP Henkind
Mar 1, 1976·The British Journal of Ophthalmology·P G Watson, S S Hayreh
Nov 1, 1990·Ophthalmology·B A Rice, C S Foster
Mar 1, 1990·The British Journal of Ophthalmology·P FrithF Wojnarowska
Dec 1, 1989·The British Journal of Dermatology·S M BurgeF Wojnarowska
Mar 1, 1987·The Journal of Clinical Investigation·C MorimotoS F Schlossman
Jul 1, 1988·Clinical Immunology and Immunopathology·S RaziuddinM Kelley
Sep 1, 1988·Arthritis and Rheumatism·F J Stafford-BradyM Easterbrook
May 1, 1986·Southern Medical Journal·B Williams, D S Hull
Sep 1, 1986·Arthritis and Rheumatism·A V KlinkhoffA Chalmers
Jun 1, 1985·Clinical Immunology and Immunopathology·A G KarpikJ L Roberts
Mar 1, 1985·Ophthalmology·E M GrahamR W Russell
May 25, 1967·The New England Journal of Medicine·G L Spaeth
Apr 1, 1972·Journal of Chronic Diseases·R A Larsen
Nov 1, 1972·The British Journal of Ophthalmology·D H GoldP Henkind
May 1, 1984·Nihon rinsho. Japanese journal of clinical medicine·T Ofuji
Nov 1, 1983·Archives of Dermatology·M I JacobsJ C Bystryn
Jun 1, 1984·Ophthalmology·S C TsengW R Green
Jan 1, 1980·The Journal of Experimental Medicine·D T YuH G Kunkel
Sep 1, 1980·The American Journal of Medicine·R M BlaeseA D Steinberg
Jan 1, 1981·Immunological Reviews·A D SteinbergE S Ravecheé
Sep 10, 1981·Nature·D W MasonA N Barclay
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Oct 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·W BernauerS Lightman
Dec 1, 1954·Medicine·A M HARVEYE H SCHOENRICH
Aug 1, 1965·Archives of Ophthalmology·J A REEVES
Citations
Mar 13, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E SchmidtG Geerling
Jan 9, 2004·Ophthalmology·Jennifer E ThorneDouglas A Jabs
Oct 8, 1999·American Journal of Ophthalmology·M S Chung, W T Driebe
May 26, 1999·Survey of Ophthalmology·E M Messmer, C S Foster
Aug 7, 2004·Optometry : Journal of the American Optometric Association·David D Castells
Sep 11, 2008·The Ocular Surface·Valerie P J Saw, John K G Dart
Jan 5, 2002·Eye·A K KwokD S Lam
Jul 8, 1999·The New England Journal of Medicine
Jun 23, 2001·The New England Journal of Medicine
Aug 31, 2000·Optometry and Vision Science : Official Publication of the American Academy of Optometry·D Q Chan
Jul 21, 2006·The British Journal of Ophthalmology·S DenJ Shimazaki
Jun 29, 2010·Lupus·V PeponisV C Kyttaris
Apr 24, 2014·Journal of Ophthalmology·Maria M ChoudharyCareen Y Lowder
Oct 1, 2010·Retinal Cases & Brief Reports·Robert W WongEmmett Cunningham
Nov 1, 2008·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·E Nigel Wardle
Nov 26, 2010·Journal français d'ophtalmologie·M PoliC Burillon
Jan 15, 2008·Autoimmunity Reviews·Luis J JaraGabriela Medina
Jan 15, 2008·Veterinary Ophthalmology·M J DayW J Carter
Nov 5, 2011·Veterinary Ophthalmology·Nora DenkBruce H Grahn
Jul 20, 2012·Autoimmune Diseases·Neal V PalejwalaSteven Yeh
Feb 18, 2006·Lupus·V PeponisN M Sitaras
May 26, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·E J Lewis
May 2, 2001·The Cochrane Database of Systematic Reviews·B de, P Garner
Nov 13, 2008·Current Opinion in Ophthalmology·John B Davies, Prabakar Kumar Rao
Sep 29, 2000·Cornea·M R DanaP Hamrah
Mar 4, 2021·Survey of Ophthalmology·Yogita GuptaRadhika Tandon
Aug 20, 2021·Clinical Ophthalmology·Mohamed Salah El-Din MahmoudMohamed Farouk Abdelkader
Oct 1, 2021·BMJ Open·Lixiang WangYingping Deng