Histology far away from Flatland: 3D roller-coasting into grade-dependent angiogenetic patterns in oligodendrogliomas

Journal of Cellular and Molecular Medicine
P CassoniG Bussolati

Abstract

Angiogenesis plays a key role in tumour progression, and undergoes structural changes associated to tumour biology itself. Although vessel density can be easily evaluated in brain tumours using a traditional immuno-histochemical approach, other parameters of conceptual/biological interest, such as the complex patterns of vascular growth, cannot be fully understood using a traditional bi-dimensional evaluation. We use here surgical specimens derived from oligodendrogliomas as a model for a novel elucidative 3D reconstruction of the grade-dependent vascular arborisation in brain tumours.

References

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Citations

Aug 6, 2013·Oncogene·R H FarnsworthS A Stacker
Apr 15, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Federico RoncaroliFederico E Turkheimer
Sep 5, 2008·Virchows Archiv : an International Journal of Pathology·Sofia AsioliGianni Bussolati
Jun 6, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mattia VeroneseFederico E Turkheimer

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