PMID: 808514Sep 1, 1975

Histology of the monkey lateral geniculate nucleus after unilateral lid closure and experimental strabismus: further observations

Investigative Ophthalmology
G K von Noorden, P R Middleditch

Abstract

The histology of binocularly and monocularly innervated portions of the lateral geniculate nucleus (LGN) was studied after unilateral lid closure and experimental esotropia and exotropia in the Macaca mulatta and the results were compared with behavioral and neurophysiological data. The most severe cell shrinkage occurred in two animals who had one eye sutured during the first week of life; all dorsal and ventral deprived LGN layers, including the monocular segment, were involved. Less severe anomalies and sparing of the monocular segment were encountered in esotropic amblyopic monkeys and the least severe changes were in exotropic animals without amblyopia. The severity of behavioral, neurophysiologic, and histologic changes following unilateral lid suture or experimental strabismus could be correlated in all animals studied. The data indicate that the order of susceptibility of the LGN to reduced or abnormal visual input early in life appears to be: dorsal laminae greater than ventral laminae greater than monocular segment.

Related Concepts

Lazy Eye
Anthropoidea
Blindness, Transient
Medial Geniculate Body
Macaca mulatta
Strabismus, Noncomitant

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.