Histometric and fine-structural analysis of pig glomeruli after experimental protracted shock

Pathology, Research and Practice
W DrommerL C Schulz

Abstract

Glomeruli of control and shock-treated, 6-8-week-old pigs (n = 16 specific pathogen-free) were analyzed by light microscopy, transmission electron microscopy and morphometry. In eight of the animals the shock was induced using a neurotoxin of the E. coli serotype O 139: k82 (B). The animals were killed 47 to 264 hours post injection. In semithin sections a significant mesangial widening and increase of the mesangial nuclei count was demonstrated. The volume of the mesangium was 11.1% in the control animals and increased to 19.6% after protracted shock. By electron microscopy we ascertained a distinct activation of the mesangial cells concomitant with an increase of ribosomes, rough endoplasmatic reticulum, lysosomes and a fusion of the epithelial pedicles. The surrounding mesangial matrix was enlarged. In this paper the significance of this mesenchymal reaction in relation to shock situations is discussed.

References

May 1, 1978·Pathology, Research and Practice·W SandritterH Grimm
Mar 5, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·B van Bamme, J Koudstaal
Jan 1, 1977·Diabetologia·H J Gundersen, R Osterby
Jun 7, 1974·Deutsche medizinische Wochenschrift·H P Seelig, R Seelig

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Citations

Apr 1, 1984·The Journal of Urology·V E TorresR E Ritts
Jul 1, 1984·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·M RosenbruchF J Kaup

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