PMID: 11322400Apr 27, 2001Paper

Histomorphologic and volumetric analysis of implanted autologous preadipocyte cultures suspended in fibrin glue: a potential new source for tissue augmentation

Aesthetic Plastic Surgery
T SchoellerArian Mowlawi

Abstract

Previous efforts to use adipocyte transplants for tissue augmentation have been limited by high and unpredictable resorption rates. Preadipocytes are precursor cells that are capable of replication and differentiation into mature adipocytes. Furthermore, they are more resilient to ischemia, making them a desirable transplant media. Utilizing fibrin glue as a transport vehicle and a prefabricated intramuscular capsule pouch as the recipient site, we have demonstrated the successful transplantation of cultured preadipocytes without the previously presented resorption sequelae. Histological analysis at 2 weeks has demonstrated establishment of vascular supply and the complete resorption of fibrin glue. Most importantly, using planimetric analysis, volume retention has been demonstrated in implanted areas up to 1 year following implantation. Finally, BrdU labeling has been utilized to demonstrate the lack of increased and uncontrolled replication rate, an index of potentially tumorigenic tissue. In conclusion, we have demonstrated a potentially new and safe source of tissue augmentation in the rat model.

Citations

Mar 24, 2007·Aesthetic Plastic Surgery·Nestor Torio-PadronJoerg Borges
Sep 7, 2007·Aesthetic Plastic Surgery·Bruno AzzenaVincenzo Vindigni
Nov 21, 2008·Aesthetic Plastic Surgery·Regina KhaterVeronique Martinot-Duquennoy
Apr 23, 2011·Aesthetic Plastic Surgery·Gwendolyn HobenRaymund E Horch
Nov 19, 2003·Clinics in Plastic Surgery·Elisabeth K BeahmCharles W Patrick
Dec 31, 2003·Biomaterials·Thomas SchoellerGottfried Wechselberger
Jun 12, 2008·Tissue Engineering. Part B, Reviews·Charles W PatrickCindy Frye
May 25, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Seong-Ho JeongWoo-Kyung Kim
Oct 27, 2006·Expert Review of Medical Devices·Karsten Hemmrich, Dennis von Heimburg
May 19, 2006·Expert Opinion on Biological Therapy·Anna M Parker, Adam J Katz
Jul 26, 2003·Expert Opinion on Biological Therapy·Jeffrey M Gimble
Apr 28, 2012·Facial Plastic Surgery Clinics of North America·Anthony P Sclafani, Masoud Saman
May 18, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·N Torio-PadronA M Huotari
Jul 3, 2003·The Laryngoscope·Frank R GlatzArian Mowlawi
Aug 5, 2011·Journal of Tissue Engineering and Regenerative Medicine·A Peterbauer-ScherbS Wolbank
Mar 2, 2011·Journal of Tissue Engineering and Regenerative Medicine·Femke VerseijdenGerjo J V M van Osch
Sep 28, 2010·Burns : Journal of the International Society for Burn Injuries·Maike KeckManfred Frey
May 6, 2014·Frontiers in Neuroengineering·Elisa CastagnolaLuciano Fadiga
Feb 13, 2015·Plastic and Reconstructive Surgery. Global Open·Cormac W JoyceJack L Kelly
Jun 16, 2016·Scientific Reports·Mohit P ChhayaJan-Thorsten Schantz
Apr 17, 2010·Advanced Drug Delivery Reviews·Petra Bauer-KreiselTorsten Blunk
Oct 12, 2011·Skin Pharmacology and Physiology·C LequeuxA Mojallal
Jan 8, 2013·Journal of Burn Care & Research : Official Publication of the American Burn Association·Shanmugasundaram NatesanRobert J Christy
Jan 10, 2013·Journal of Wound Care·C J Lewis
Jul 11, 2012·Plastic and Reconstructive Surgery·Maarten A J DoornaertPhillip Blondeel

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