Histomorphology and innate immunity during the progression of osteoarthritis: Does synovitis affect cartilage degradation?

Journal of Cellular Physiology
Huan WangQingfu Wang

Abstract

Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological stages of the disease. In the present study, our aim was to assess changes in innate immunity during the pathological processes of OA in articular cartilage (AC) and the synovial membrane (SM), which are the major structures in joints, and to systematically examine the histological changes in AC and SM in mild, moderate and severe cases of OA, in order to further speculate about the manner in which the interactions of AC and SM are facilitated by innate immunity. Histological methods (including HE and Safranin O-fast green staining), immunofluorescent double staining, TUNEL stain, and Western blots were used to assess the morphological changes within AC and SM tissues in healthy and mild, moderate, or severe OA rats. Our results showed that the damage to AC and SM within the joints progressively worsened in different degrees during the course of the disease, and that the innate immune system was closely involved in...Continue Reading

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Citations

Feb 13, 2019·International Journal of Rheumatic Diseases·Xiaoyun PengZhaoxia Wang
Sep 25, 2019·International Journal of Molecular Sciences·Cleydlenne Costa VasconcelosMaria do Socorro de Sousa Cartágenes
Mar 11, 2020·Journal of Orthopaedic Surgery and Research·Pu ChenQingfu Wang
Jun 12, 2020·Organic & Biomolecular Chemistry·Jianhua LiaoRenshi Luo
Nov 6, 2020·Drug Design, Development and Therapy·Guang YangSiying Li
Oct 15, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Shouqian DaiHuilin Yang
Jul 23, 2021·Journal of Inflammation Research·Yuki YamanashiMasataka Deie

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