PMID: 3768197Jan 1, 1986Paper

Histomorphometric analysis of a calcaneal stress fracture: a possible complication of fluoride therapy for osteoporosis

Bone
C M Schnitzler, L Solomon

Abstract

Pain and swelling of the large joints of the lower limbs occur in about 33% of patients receiving sodium fluoride, calcium, and vitamin D therapy. In a previous study we described radiographic and scintigraphic features suggesting that these symptoms are due to juxtaarticular stress fractures. We now report the histologic features of one such lesion in a calcaneum of a patient receiving fluoride, calcium, and 1 alpha-vitamin D therapy for postmenopausal osteoporosis. Bone biopsy after tetracycline double labeling showed a trabecular fissure fracture and large intratrabecular resorption cavities surrounded by microcallus. Comparison of the static and dynamic histomorphometric parameters in the calcaneum with those in the simultaneously taken iliac bone biopsy showed a marked regional acceleratory phenomenon in the calcaneum that we ascribe to the microfractures. It cannot be said with certainty whether the microfractures resulted from the osteoporosis, the vitamin D, or the sodium fluoride therapy.

Citations

Feb 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M SchnitzlerA E Smyth
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C M SchnitzlerA E Smyth
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D H GutteridgeP A Michell
Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P OrcelG Kaplan
Nov 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G BoivinP J Meunier
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A BattmannD J Baylink
Apr 1, 1991·Baillière's Clinical Rheumatology·M Laroche, B Mazières
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
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Dec 1, 1992·Bone and Mineral·H M Frost
Feb 5, 2002·Expert Opinion on Pharmacotherapy·C S di Fazano, P Bertin
Apr 1, 1996·Critical Reviews in Clinical Laboratory Sciences·M Kleerekoper
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Jun 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M KleerekoperA M Parfitt
Jun 10, 2004·Clinical Orthopaedics and Related Research·Kazuo ItoHideji Kura
Aug 1, 2019·Clinical Reviews in Bone and Mineral Metabolism·Benjamin OsipovBlaine A Christiansen
Mar 1, 1989·La Revue de médecine interne·C MarcelliL Simon

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