Histomorphometric analysis of intrapulmonary vessels in patients undergoing bidirectional Glenn shunt and total cavopulmonary connection

The Journal of Thoracic and Cardiovascular Surgery
Ujjwal K ChowdhurySrikrishna M Reddy

Abstract

The purposes of this study were to elucidate the histomorphometry of the intrapulmonary arteries in patients undergoing univentricular type of repairs and to identify the histomorphometric characteristics, if any, that may predispose patients to postoperative Fontan failure. Operatively resected wedges of lung tissue from 44 patients undergoing univentricular type of repairs (aged 17 months to 34 years; mean, 83.52 ± 75.90 months) was subjected to histomorphometric analysis. Despite pulmonary arterioplasty, a low Nakata index was associated with 9.61 (95% confidence interval: 1.01-91.5; P = .003) times increased risk of death after the operation. A statistically significant difference in the mean indexed diameter of the intra-acinar pulmonary arteries (P = .03) was observed between patients undergoing superior and total cavopulmonary connections. Overall, there were 8 (8.2%), 4 (9.1%), 13 (29.5%), and 29 (65.9%) instances of intrapulmonary arterial intimal lesions, thrombosis, smooth muscle extension, and interstitial fibrosis, respectively. Among patients undergoing total cavopulmonary connection, only low Nakata index was significantly associated with the presence of severe intimal lesions, abnormal smooth muscle extension, i...Continue Reading

References

May 1, 1985·British Heart Journal·E Juaneda, S G Haworth
Jan 1, 1981·The American Journal of Cardiology·M RabinovitchL Reid
Jul 1, 1998·The Annals of Thoracic Surgery·M MasudaH Yasui
Jul 28, 2004·The Annals of Thoracic Surgery·Ujjwal K ChowdhuryPanangipalli Venugopal
Jul 26, 2005·The Annals of Thoracic Surgery·Ujjwal K ChowdhuryPanangipalli Venugopal

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Citations

Mar 31, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Floris-Jan S RidderbosRolf M F Berger
Oct 1, 2020·Journal of Cardiothoracic Surgery·Ryosuke KowatariIkuo Fukuda
Nov 9, 2019·World Journal for Pediatric & Congenital Heart Surgery·Sara C ArrigoniTjark Ebels

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