Histomorphometric and biochemical study of osteoclasts at orthodontic compression sites in the rat during indomethacin inhibition

Archives of Oral Biology
D ZhouG J King

Abstract

Prostaglandins affect the number of osteoclasts at compression sites in orthodontic tooth movement. They may also have a role in tooth movement and influence the extent of root resorption. The purpose was to examine the effect of indomethacin on the activity of resident osteoclasts, recruitment of new osteoclasts and root resorption at orthodontic compression sites. Two separate populations of osteoclasts were studied: those resident at the sites after initial appliance activation and those recruited by a subsequent activation. Orthodontic appliances were activated to provide mesially directed forces of 40 g on the maxillary molars of rats. The appliances were activated with the same force after 4 days. The rats were killed at 1, 3, 6 and 10 days after initial activation. Half of the rats were injected with indomethacin. Tooth movement was measured cephalometrically; osteoclast numbers, sizes, numbers of nuclei per osteoclast and root resorption were assessed histomorphometrically; tartrate-resistant acid phosphatase (TRAP) in alveolar bone was measured biochemically. Indomethacin inhibited both initial tooth displacement and that following the delay. It also reduced the increase in osteoclast numbers, total osteoclast surface ...Continue Reading

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