Histomorphometric and microarchitectural analyses using the 2 mm bone marrow trephine in metastatic breast cancer patients-preliminary results

Journal of Bone Oncology
M FralickMark Clemons

Abstract

Bone-targeted agents are widely used for the treatment of osteoporosis, the prevention of cancer-therapy induced bone loss, and for reducing the risk of skeletal related events in patients with metastatic disease. Despite widespread use, relatively little is known about the in vivo effect of these agents on bone homeostasis, bone quality, and bone architecture in humans. Traditionally bone quality has been assessed using a transiliac bone biopsy with a 7 mm "Bordier" core needle. We examined the possibility of using a 2 mm "Jamshidi" core needle as a more practical and less invasive method to assess bone turnover and potentially other tumor effects. A pilot study on the feasibility of assessing bone quality and microarchitecture and tumor invasion using a 2 mm bone marrow trephine was conducted. Patients underwent a posterior trans-iliac trephine biopsy and bone marrow aspirate. Samples were analyzed for bone microarchitecture, bone density, and histomorphometry. The study plan was to accrue three patients with advanced breast cancer to assess the feasibility of the study before enrolling more patients. The procedure was well tolerated. The sample quality was excellent to analyze bone trabecular microarchitecture using both mic...Continue Reading

Citations

Aug 15, 2014·Current Opinion in Supportive and Palliative Care·Carmel JacobsMark Clemons
Jan 1, 2013·Journal of Clinical Medicine·Demetrios SimosMark Clemons
Mar 29, 2014·Expert Opinion on Pharmacotherapy·Carmel JacobsMark Clemons

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Methods Mentioned

BETA
X-ray
biopsies
biopsy

Software Mentioned

Photoshop
Osteomeasure

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