Histomorphometric evaluation of the effects of zoledronic acid on mandibular distraction osteogenesis in rabbits

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
A Alper PampuReha S Kişnişci

Abstract

To assess the effect of systemic administration of zoledronic acid (ZA) on mineralization of newly formed bone and to determine strain-related osteoporosis on surrounding bone during lengthening of immature rabbit mandible. Eighteen New Zealand white rabbits were divided randomly into 2 groups, and bone lengthening was carried out in the left portion of the mandible through distraction osteogenesis with a rate of 0.5 mm every 12 hours for 5 days. The experimental group was administered 0.1 mg/kg ZA intravenously. The control group was given saline infusion only during operation. All animals were sacrificed at the end of the 28-day consolidation period. The mandibles of all animals were removed and regenerate was evaluated. Osteoblasts, osteoclasts, collagen fibers, and fibroblasts were marked within 0.1-mm(2) area and newly formed bone area was measured within 0.5-mm(2) area. All data were analyzed using Mann-Whitney U test. Although irregular bone destruction spots were seen in the control group, the experimental group showed regular ossification areas and significant difference between osteoblast and osteoclast numbers (P < .05). In the regenerate zone, there was considerable difference between the 2 groups in terms of osteob...Continue Reading

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Citations

Apr 23, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Paul HongMichael Bezuhly
Jan 1, 2011·Annals of Maxillofacial Surgery·Marcello Gaieta VannucciMarilia Gerhardt de Oliveira
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Oct 25, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yusheng YaoChunming Liu
Sep 29, 2011·International Journal of Oral and Maxillofacial Surgery·Dervişhan KüçükCesur Gümus
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