PMID: 2503923Jan 1, 1989Paper

Histomorphometry of bone marrow biopsies in primary osteomyelofibrosis/-sclerosis (agnogenic myeloid metaplasia)--correlations between clinical and morphological features

Virchows Archiv. A, Pathological Anatomy and Histopathology
J ThieleR Fischer

Abstract

Histomorphometry was performed on representative trephine biopsies of the bone marrow on admission of 50 patients (21 male, 29 female - age 67 years) with so-called primary osteomyelofibrosis/-sclerosis (OMF) not preceded by any other subtype of chronic myeloproliferative disorders. This study was firstly aimed at testing correlations between histological features (amount of haematopoiesis, cytological aspects of megakaryocytes, density of reticulin and collagen fibres and degree of osteosclerosis) and laboratory data, as well as spleen size and duration of relevant prediagnostic symptoms. Secondly, we concentrated on a discrimination of OMF patients into two subgroups according to bone marrow morphology and clinical variables. Statistical evaluation of histomorphometric variables and haematological findings disclosed that there was a progressive fibro-osteosclerotic process in the evolution of disease features. Increase in medullary fibrosis was significantly paralleled by an abnormal or pleomorphic megakaryopoiesis in the bone marrow: there was an increase in irregularity of perimeters for megakaryocytes and naked nuclei combined with smaller sizes of these elements including the nuclei. Additionally, there was a greater numb...Continue Reading

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Citations

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·J Thiele, R Fischer
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·S FalkH J Stutte
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·V KaloutsiA Georgii
Jan 1, 1993·International Journal of Clinical & Laboratory Research·H C Hasselbalch
Jun 26, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Jürgen Thiele, Hans M Kvasnicka
Dec 1, 1994·Leukemia & Lymphoma·A M CohenM Djaldetti
Jan 7, 2006·Leukemia & Lymphoma·Juergen Thiele, Hans M Kvasnicka
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Jul 17, 2009·American Journal of Clinical Pathology·Juergen Thiele
Oct 22, 2009·American Journal of Hematology·Hans Michael Kvasnicka, Juergen Thiele
Jun 20, 2006·Best Practice & Research. Clinical Haematology·J ThieleJ Vardiman
Oct 8, 2005·Seminars in Hematology·Juergen ThieleAttilio Orazi
Aug 15, 1997·Cancer·H M KvasnickaR Fischer
Oct 24, 2002·Blood·Hédia ChagraouiFrançoise Wendling
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Orianne Wagner-BallonStéphane Giraudier

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