Histone acetylation: a possible mechanism for the inheritance of cell memory at mitosis

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
P Jeppesen

Abstract

Immunofluorescent labelling demonstrates that human metaphase chromosomes contain hyperacetylated histone H4. With the exception of the inactive X chromosome in female cells, where the bulk of histone H4 is underacetylated, H4 hyperacetylation is non-uniformly distributed along the chromosomes and clustered in cytologically resolvable chromatin domains that correspond, in general, with the R-bands of conventional staining. The strongest immunolabelling is often found in T-bands, the subset of intense R-bands having the highest GC content. The majority of mapped genes also occurs in R-band regions, with the highest gene density in T-bands. These observations are consistent with a model in which hyperacetylation of histone H4 marks the position of potentially active gene sequences on metaphase chromosomes. Since acetylation is maintained during mitosis, progeny cells receive an imprint of the histone H4 acetylation pattern that was present on the parental chromosomes before cell division. Histone acetylation could provide a mechanism for propagating cell memory, defined as the maintenance of committed states of gene expression through cell lineages.

References

May 1, 1992·Trends in Genetics : TIG·A D Riggs, G P Pfeifer
Jul 10, 1992·Cell·A Bird
Mar 11, 1992·Nucleic Acids Research·T R HebbesC Crane-Robinson
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J Hayes, A P Wolffe
Mar 23, 1990·Cell·J Tazi, A Bird
Jan 1, 1990·The Biochemical Journal·A Csordas
Jun 16, 1989·Cell·S HandeliH Cedar
Jan 1, 1986·CRC Critical Reviews in Biochemistry·R S WuW M Bonner
Jan 1, 1985·Cytogenetics and Cell Genetics·P J McAlpineA J Pakstis
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S A Latt
Oct 11, 1984·Nature·T J RichmondA Klug
Jul 28, 1995·The Journal of Biological Chemistry·M Garcia-RamirezJ Ausio
Jan 1, 1994·Developmental Genetics·A P Wolffe
Jul 1, 1994·Nature Genetics·J M Craig, W A Bickmore
Dec 20, 1993·FEBS Letters·A L ClaytonC Crane-Robinson
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B R MigeonJ E Wiley
Apr 1, 1993·Genes & Development·M BraunsteinJ R Broach
May 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·V G ALLFREYA E MIRSKY
Mar 1, 1962·Experimental Cell Research·D M PRESCOTT, M A BENDER

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Citations

Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B M Turner
Aug 23, 2012·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Wolfgang Staiber
Jul 11, 2002·Mutation Research·G ObeM E Drets
Sep 5, 1998·Mutation Research·J SurrallésA T Natarajan
Apr 2, 1999·The European Journal of Neuroscience·R DaoudS Stamm
Sep 3, 1998·Molecular Biology of the Cell·M J HendzelD P Bazett-Jones
Jun 5, 1999·The EMBO Journal·J KoipallyK Georgopoulos
Jul 22, 1998·Nucleic Acids Research·O NaylerS Stamm
Jan 29, 2000·Molecular and Cellular Biology·H H NgA Bird
Feb 8, 2006·Respiratory Research·Ian M AdcockP J Barnes
Sep 14, 2010·The Journal of Reproduction and Development·Min-Jung LeeDong-Hoon Kim
Nov 20, 1998·Biological Chemistry·J BuzekB Vyskot
Oct 12, 2012·Biologics : Targets & Therapy·Judith M Greer, Pamela A McCombe
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·S MinucciK Ozato
Jul 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jordi SurrallésLeon H F Mullenders
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·J KoipallyK Georgopoulos
Feb 9, 2011·The Journal of Cell Biology·Myriam RuaultAngela Taddei
Jul 2, 2003·The Journal of Cell Biology·Jin-Moon KimFugaku Aoki
Feb 10, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Marcello Barbieri
Apr 12, 2008·Mutation Research·Laura Lafon-HughesWilner Martínez-López
May 15, 2012·Medicinal Research Reviews·Junyan LuKeqin Kathy Li
Mar 10, 2010·Environmental and Molecular Mutagenesis·Ofelia A OliveroGraciela Spivak
Sep 29, 2005·Trends in Biochemical Sciences·Kevin D Sarge, Ok-Kyong Park-Sarge
Dec 18, 1997·American Journal of Human Genetics·R Feil, G Kelsey
Dec 22, 2011·International Journal of Epidemiology·David Haig
Dec 21, 2006·International Journal of Radiation Biology·M V Di TomasoF Palitti

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