Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

Clinical Epigenetics
Yanshuo HanJaroslav Pelisek

Abstract

Epigenetic modifications may play a relevant role in the pathogenesis of human abdominal aortic aneurysm (AAA). The aim of the study was therefore to investigate histone acetylation and expression of corresponding lysine [K] histone acetyltransferases (KATs) in AAA. A comparative study of AAA tissue samples (n = 37, open surgical intervention) and healthy aortae (n = 12, trauma surgery) was performed using quantitative PCR, immunohistochemistry (IHC), and Western blot. Expression of the KAT families GNAT (KAT2A, KAT2B), p300/CBP (KAT3A, KAT3B), and MYST (KAT5, KAT6A, KAT6B, KAT7, KAT8) was significantly higher in AAA than in controls (P ≤ 0.019). Highest expression was observed for KAT2B, KAT3A, KAT3B, and KAT6B (P ≤ 0.007). Expression of KAT2B significantly correlated with KAT3A, KAT3B, and KAT6B (r = 0.705, 0.564, and 0.528, respectively, P < 0.001), and KAT6B with KAT3A, KAT3B, and KAT6A (r = 0.407, 0.500, and 0.531, respectively, P < 0.05). Localization of highly expressed KAT2B, KAT3B, and KAT6B was further characterized by immunostaining. Significant correlations were observed between KAT2B with endothelial cells (ECs) (r = 0.486, P < 0.01), KAT3B with T cells and macrophages, (r = 0.421 and r = 0.351, respectively, P < 0...Continue Reading

References

Nov 27, 1992·Cell·T R HuppD P Lane
Nov 18, 1996·Annals of the New York Academy of Sciences·W H Pearce, A E Koch
Jun 19, 1997·Nature·W GuR G Roeder
Aug 24, 1999·Molecular and Cellular Biology·K A SheppardT Collins
Sep 25, 1999·The Journal of Biological Chemistry·N ChampagneX J Yang
Feb 17, 2000·The EMBO Journal·M A Martínez-BalbásT Kouzarides
May 19, 2001·European Journal of Biochemistry·S R Grossman
Aug 11, 2001·Science·T Jenuwein, C D Allis
Sep 5, 2001·Current Opinion in Genetics & Development·T A McKinseyE N Olson
May 10, 2002·The New England Journal of Medicine·Robert W Thompson
Nov 7, 2002·The Journal of Biological Chemistry·Rosemary KiernanMonsef Benkirane
Jun 16, 2004·Current Opinion in Genetics & Development·Yannick Doyon, Jacques Côté
May 4, 2005·Lancet·N SakalihasanO D Defawe
Oct 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helena Santos-Rosa, Carlos Caldas
Jul 25, 2006·Critical Reviews in Biochemistry and Molecular Biology·Mary C Thomas, Cheng-Ming Chiang
Mar 14, 2007·Journal of Vascular Surgery·Jian ZhangJens R Allenberg
Jul 7, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S S M RensenG J J M van Eys
Nov 21, 2007·Cell·C David AllisYi Zhang
Jul 11, 2008·DNA and Cell Biology·Priyanka SharmaShantanu Sengupta
Sep 16, 2008·Journal of Molecular Biology·Xueyan Zhao, Etty N Benveniste
Apr 3, 2009·Genes & Development·Shelley L BergerAli Shilatifard
Oct 10, 2009·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Christian ReepsHans-Henning Eckstein
Mar 30, 2010·Atherosclerosis·Smriti M KrishnaJonathan Golledge
May 8, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Mingdi YinShijie Xin
Jun 12, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·W R W WilsonM M Thompson
Jan 12, 2012·Archiv der Pharmazie·Silviya D FurdasManfred Jung
Jun 22, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Antonius J N M BastiaansenPaul H A Quax
May 23, 2015·Thrombosis and Haemostasis·A GreißelJ Pelisek

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Citations

Apr 4, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jingzhe ZhangWenjun Wang
Jan 21, 2020·Clinical Genetics·Kevin D Mangum, Mark A Farber
Sep 30, 2018·Biophysics Reviews·Stefanie S PortelliRichmond W Jeremy
Sep 4, 2020·International Journal of Molecular Sciences·Rijan GurungVitaly Sorokin
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Jacob GreenwayNeal L Weintraub
Mar 30, 2021·The Journal of Experimental Medicine·Frank M DavisKatherine A Gallagher
May 15, 2021·Life Sciences·Alejandra Zúñiga-MuñozMabel Buelna-Chontal
Jul 27, 2021·Oxidative Medicine and Cellular Longevity·Yanshuo HanJian Zhang

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Methods Mentioned

BETA
histone acetylation
dot blots
acetylation
acetylates
PCR
Protein Assay

Software Mentioned

SPSS

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