Histone acetylation/deacetylation and cancer: an "open" and "shut" case?

Current Molecular Medicine
S G Gray, B T Teh

Abstract

DNA in eukaryotic cells is packaged into chromatin. The main packaging component of chromatin is the nucleosome, and this is composed of proteins known as histones. Histones can be reversibly modified in several ways, and the best characterized of these modifications is histone acetylation. This is a reversible modification, which is carried out by two families of enzymes, the histone acetyltransferases (HATs), and the histone deacetylases (HDACs). These enzymes have important activities in many cellular processes including transcription, DNA replication and cell cycle progression. The mechanisms underlying tumor formation are multifaceted, and often involve mutations or alterations of genes involved with the regulation and control of the cell cycle or cell death. Because of their important roles in the regulation of such events, enzymes that affect histone acetylation status are increasingly being associated with tumors. This article describes some of the current knowledge about histone acetyltransferases and histone deacetylases, and how their multitudinal roles in cellular events may have important roles in tumorigensis.

Citations

Dec 8, 2010·Cell Biochemistry and Biophysics·Shahper N KhanAsad U Khan
May 2, 2009·Archives of Pharmacal Research·Su-Nam KimYong Kee Kim
Nov 30, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xia ZhaoGuosheng Jiang
Mar 31, 2005·Biochemical and Biophysical Research Communications·Ai-Guo WangDong-Seok Lee
May 21, 2013·Progress in Biophysics and Molecular Biology·Yury E Shapiro
Jun 21, 2005·Molecular and Cellular Biology·Shashirekha ShettySpencer B Gibson
Jan 10, 2012·World Journal of Gastroenterology : WJG·Long-Zhu LiJun-Ming Guo
Oct 30, 2013·Journal of Cancer Research and Therapeutics·Lin ZhangBin Wang
Mar 27, 2007·The International Journal of Biochemistry & Cell Biology·Holger Hess-StumppOliver Politz
Sep 1, 2015·The Journal of Investigative Dermatology·Elisabetta DamianiStephen E Ullrich
Dec 19, 2003·Expert Opinion on Investigational Drugs·Roberto R Rosato, Steven Grant
Aug 9, 2005·Expert Opinion on Therapeutic Targets·Roberto R Rosato, Steven Grant
Aug 16, 2006·Journal of Atherosclerosis and Thrombosis·Hiroshi OkamotoMitsuhiro Yokoyama
May 26, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Sharmila Shankar, Rakesh K Srivastava
Sep 19, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Usha SinghJasbir Kaur
Oct 6, 2005·Biological & Pharmaceutical Bulletin·Ai-Guo WangDong-Seok Lee
Sep 26, 2007·Biochemical and Biophysical Research Communications·Byung Lae ParkHyoung Doo Shin
Sep 25, 2003·Genes, Chromosomes & Cancer·Max M van NoeselRogier Versteeg
Jan 25, 2020·Journal of Ophthalmology·Michele LanzaClaudio Napoli
Jul 4, 2003·The Journal of Nutrition·James R Davie
Jun 2, 2005·The Journal of Biological Chemistry·Steven G GrayFernando Dangond
Jan 27, 2011·Journal of Cellular Biochemistry·You Mie Lee
May 21, 2005·Diabetes/metabolism Research and Reviews·Steven G Gray, Pierre De Meyts
Aug 8, 2020·Molecular & Cellular Proteomics : MCP·Javier RodriguezAlex von Kriegsheim
Oct 18, 2005·Molecular Cancer Therapeutics·Lindsay StimsonG Wynne Aherne
Apr 5, 2005·Cancer Research·Kelly J ReichenbergerHeide L Ford
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Clifton Lee DalgardJoan M O'Brien

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.