Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.

Cancer Letters
Michael R GarbatiT D Gilmore

Abstract

Human c-Rel (REL) is a member of the NF-kappaB family of transcription factors. REL's normal physiological role is in the regulation of B-cell proliferation and survival. The REL gene is amplified in many human B-cell lymphomas and overexpression of REL can transform chicken lymphoid cells. In this report, histone acetyltransferase p300 enhanced REL-induced transactivation and interacted with REL both in vitro and in REL-transformed chicken spleen cells and the B-lymphoma cell line RC-K8, in which REL is constitutively active and required for proliferation. However, due to a deletion in the EP300 locus, only a C-terminally truncated form of p300 is expressed in RC-K8 cells. These results suggest a role for p300 in REL-mediated oncogenic activity in B lymphoma.

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Citations

Mar 11, 2011·Nature·Laura PasqualucciRiccardo Dalla-Favera
May 18, 2011·Current Opinion in Hematology·Rita Shaknovich, Ari Melnick
Dec 30, 2010·Molecular and Cellular Biology·Francis S WolenskiThomas D Gilmore
Nov 3, 2010·The Journal of Clinical Investigation·Leandro C CerchiettiAri Melnick
Sep 9, 2011·PLoS Pathogens·Heather L HowieDenise A Galloway
Jun 19, 2015·Leukemia & Lymphoma·Concepción Fernández-RodríguezBlanca Sanchez-Gonzalez
Mar 24, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·X HouH-X Yang
Mar 26, 2015·Seminars in Hematology·Yanwen Jiang, Ari Melnick
Oct 31, 2017·Developmental and Comparative Immunology·Leah M WilliamsThomas D Gilmore

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