Abstract
The histone acetyltransferases (HATs) adenovirus E1A-associated protein (p300) and CREB binding protein (CBP) serve as coactivators during a diverse assortment of cellular processes. In the present study, p300 and CBP were highly expressed in 5 gastric cancer (GC) cell lines (SGC‑7901, MKN45, MGC-803, BGC-823 and KATO III) compared with human normal gastric epithelial cell line (GES-1). C646, a selective inhibitor of p300 and CBP, inhibited cell viability and cell cycle and promoted cell apoptosis in all 5 GC cell lines. In addition, C646 suppressed the migration and invasion capability of the GC cell lines, except for the middle-differentiated SGC-7901 cell line. Furthermore, we detected the differential expression of corresponding oncogenic signalling molecules, such as c-Met, Akt, Bcl-2, Bax, cyclin D1, MMP7 and MMP9, in GC cells following C646 treatment. In conclusion, our results suggest that C646 inhibits the acetylation of histone H3 via inactivation of p300 and CBP, resulting in antineoplastic effects toward GC cells. Thus, the selective HAT inhibitor C646 could be a promising antitumour reagent for GC treatment.
References
Jun 26, 1997·Oncogene·S SatoC R Goding
Jun 5, 1998·Trends in Genetics : TIG·R H GilesM H Breuning
Sep 25, 1999·Journal of Cellular Physiology·A Giordano, M L Avantaggiati
Oct 9, 1999·The Journal of Biological Chemistry·B N KholodenkoJ B Hoek
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marika J LinjaTapio Visakorpi
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·N Gopalakrishna IyerCarlos Caldas
Jul 8, 2005·Nature·Levi A GarrawayWilliam R Sellers
Jun 1, 1997·Trends in Cell Biology·N Shiama
Feb 5, 2008·Cancer Research·William M LinLevi A Garraway
Aug 30, 2008·Cancer Science·Takuo KatsumotoIssay Kitabayashi
Jan 19, 2011·Japanese Journal of Clinical Oncology·Makoto SakaHitoshi Katai
Jun 29, 2011·Molecular Cancer Therapeutics·Frédéric R SanterZoran Culig
Jul 19, 2011·Science·Lan WangStephen D Nimer
Jul 23, 2011·Journal of Surgical Oncology·Kenji BabaShoji Natsugoe
Nov 3, 2011·Journal of Skin Cancer·Ichiro YajimaMasashi Kato
May 31, 2012·British Journal of Cancer·T EinamaS Todo
Feb 8, 2013·PloS One·Xiao-ning GaoLi Yu
Jun 8, 2013·The FEBS Journal·David R Friedmann, Ronen Marmorstein
Oct 23, 2013·Oncology Reports·Tomoaki ItoOkio Hino
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Rong-Fei HanQiu-Ping Zhang
Jun 28, 2014·Oncology Reports·Yan ZhangFeng Ji
Jul 19, 2014·PloS One·Zhiwei JiXiaobo Zhou
Feb 16, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Nozomu FuseAtsushi Ohtsu
Apr 11, 2015·Experimental Cell Research·Ying-fei LuJin-fang Zhang
Apr 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chao HanQuancheng Kan
Jun 7, 2015·Cancer Letters·Luigi MaranoAlberto Patriti
Jun 16, 2015·Gastroenterology·Patrick Tan, Khay-Guan Yeoh
Aug 5, 2015·Molecular Medicine Reports·Bin WeiXiao Gang Zhong
Oct 23, 2015·Journal of Virology·Hye-Ra LeeJae U Jung
Dec 24, 2015·Oncotarget·David PaladinoJames Turkson
May 6, 2016·Oncotarget·Yan WuYongchang Chen
Oct 26, 2016·Oncotarget·Hong GaoZhenglun Zhu
Oct 26, 2016·Oncology Reports·Meng-Li GuFeng Ji
Sep 30, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shuang LiYi Ba
Mar 16, 2017·Molecular Cancer·Xiaoqing HeYon Rojanasakul
Citations
Apr 23, 2020·International Journal of Oncology·Yi ZhouXiao Yu
Dec 19, 2019·Frontiers in Genetics·Victor G MartinezJesus Maria Paramio
Dec 25, 2019·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Aug 14, 2020·Cells·Radoslav AleksandrovAnastas Gospodinov
Jun 12, 2020·Scientific Reports·Rosemarie KruparSven Perner
Jun 14, 2020·International Journal of Molecular Sciences·Balázs Zoltán Zsidó, Csaba Hetényi
Apr 25, 2019·International Journal of Molecular Sciences·Rossana CocchiolaMargherita Eufemi
Jan 26, 2021·Cell Cycle·Zhimin WangDongjun Liu
Dec 3, 2020·Frontiers in Oncology·Donglu WuDa Liu
Jan 2, 2021·World Journal of Gastroenterology : WJG·Meng-Li GuFeng Ji
Jan 5, 2021·Curēus·Christopher HillyarJajini Varghese
Dec 17, 2020·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Mar 19, 2021·Cell Death & Disease·Junjie GuRobert Chunhua Zhao
Apr 4, 2021·Biomolecules·Chenise O'GarroShiraz Mujtaba
Mar 2, 2021·ChemMedChem·Christine S W Law, Keng Y Yeong
May 14, 2021·Scientific Reports·Hiroaki OnoMinoru Tanabe
Jun 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yi WangBo Liu
Dec 5, 2021·BMC Genomics·Marina ChoppinSusanne Foitzik