Histone carbonylation occurs in proliferating cells

Free Radical Biology & Medicine
José Luis García-GiménezFederico V Pallardó

Abstract

Chromatin is a dynamic structure formed mainly by DNA and histones, and chemical modifications on these elements regulate its compaction. Histone posttranslational modifications (PTMs) have a direct impact on chromatin conformation, controlling important cellular events such as cell proliferation and differentiation. Redox-related posttranslational modifications may have important effects on chromatin structure and function, offering a new intriguing area of research termed "redox epigenetics." Little is known about histone carbonylation, a PTM that may be related to modifications in the cellular redox environment. The aim of our study was to determine the carbonylation of the various histones during cell proliferation, a moment in cell life during which important redox changes take place. Here, we describe changes in histone carbonylation during cell proliferation in NIH3T3 fibroblasts. In addition, we have studied the variations of poly(ADP-ribosyl)ation and phospho-H2AX at the same time, because both modifications are related to DNA damage responses. High levels of carbonylation on specific histones (H1, H1(0), and H3.1 dimers) were found when cells were in an active phase of DNA synthesis. The modification decreased when nu...Continue Reading

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Citations

Apr 2, 2013·Antioxidants & Redox Signaling·José Luis García-GiménezFederico V Pallardó
Jun 21, 2013·Expert Review of Molecular Diagnostics·Juan SandovalJosé Luis García-Giménez
Sep 9, 2015·Biochimica Et Biophysica Acta·Annalisa Izzo, Schneider Robert
Jul 16, 2013·Free Radical Biology & Medicine·José Luis García-GiménezFederico V Pallardó
Oct 17, 2012·Biochimica Et Biophysica Acta·José Luis García-GiménezFederico V Pallardó
Jun 6, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·J L García-GiménezF V Pallardó
Nov 16, 2013·Journal of Attention Disorders·Nidhin JosephStephen V Faraone
Feb 13, 2019·Molecular Oncology·Juan Miguel BaqueroAna Osorio
Jun 12, 2019·BioFactors·José Luis García-GiménezFederico V Pallardó
Mar 10, 2015·Biochemistry. Biokhimii︠a︡·E V KalininaM D Novichkova
Aug 20, 2019·Journal of Experimental Botany·Christine H FoyerFrank Van Breusegem
Nov 5, 2020·Pharmacology & Therapeutics·Elena KunadisChristina Piperi
Mar 11, 2021·Free Radical Biology & Medicine·José-Luis García-GiménezFederico V Pallardó

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