Histone deacetylase 1 promotes glioblastoma cell proliferation and invasion via activation of PI3K/AKT and MEK/ERK signaling pathways

Brain Research
Shun LiGuozheng Xu

Abstract

Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and molecular mechanism in glioblastoma is poorly understood. In this study, our findings demonstrated that protein and mRNA levels of HDAC1 were increased in glioma cell lines and glioma tissues compared to normal glial cell lines and non-neoplastic brain tissues, respectively. Furthermore, HDAC1 knockdown cells displayed decreased proliferation and invasion capabilities, whereas HDAC1 overexpressing glioblastoma cells displayed more proliferation and invasion capabilities in vitro. These novel outcomes suggested that knockdown of HDAC1 possibly suppressed the expression of phosphorylated AKT (p-AKT) and phosphorylated ERK (p-ERK) proteins, while overexpression of HDAC1 significantly increased p-AKT and p-ERK protein in glioblastoma cells. In addition, knockdown of HDAC1 repressed subcutaneous tumor growth in vivo, and led to down-regulation of p-AKT and p-ERK protein in U87 MG xenograft tumors. For the first time, we ...Continue Reading

Citations

Aug 28, 2020·Frontiers in Cell and Developmental Biology·Yue HuHui Wu
Jan 18, 2020·Biomolecules·Antonia CianciulliMaria Antonietta Panaro
Nov 28, 2018·International Journal of Molecular Sciences·Karina Sánchez-AlegríaClorinda Arias
Apr 12, 2019·Frontiers in Molecular Neuroscience·Weiyang LouWeimin Fan
Nov 5, 2020·Pharmacology & Therapeutics·Elena KunadisChristina Piperi
Jan 19, 2022·Cancer Biotherapy & Radiopharmaceuticals·Qian LuSheng Huang

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