Histone deacetylase 11 inhibits interleukin 10 in B cells of subjects with allergic rhinitis

International Forum of Allergy & Rhinology
Jian-Bo ShaoPing-Chang Yang

Abstract

The interleukin (IL)-10 expression in B cells plays an important role in immune tolerance. The regulation of IL-10 expression in B cells is not fully understood yet. Tumor necrosis factor (TNF) is increased in allergic rhinitis (AR) patients. This study tests a hypothesis that TNF enhances histone deacetylase (HDAC)11 expression to inhibit the expression of IL-10 in B cells of AR patients. Peripheral B cells were collected from healthy persons and patients with AR. The B cells were analyzed by immune assay and molecular biological approaches for the expression of IL-10. The expression of HDAC11 was higher in B cells of patients with AR than that in healthy persons. The expression of IL-10 in B cells was lower in AR patients than that in healthy subjects. The levels of HDAC11 in B cells were negatively correlated with the levels of IL-10. Exposure of B cells to TNF in the culture inhibited the expression of IL-10, in which HDAC11 played a critical role in the interference with the Il10 gene transcription. Inhibition of HDAC11 restored the IL-10 expression in B cells from AR patients and attenuated the experimental AR. TNF can suppress the expression of IL-10 in B cells via enhancing the expression of HDAC11. Inhibition of HDAC11...Continue Reading

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Citations

Oct 30, 2018·International Forum of Allergy & Rhinology·Luo Zhang
Oct 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kun Xia HuXiao Song
Sep 4, 2019·Immunotherapy·Xian-Hai ZengPing-Chang Yang
Jul 30, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Joseph BeckettSushma Shankar
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena

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