Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src

Oncogene
M S Longworth, L A Laimins

Abstract

Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members remain in the nucleus. Histone deacetylase 3 often forms complexes with corepressor proteins that do not associate with the other Class I HDACs, and its phosphorylation correlates with increased enzymatic activity. Here we show that HDAC3 also localizes to the plasma membrane in multiple cell types. Furthermore, c-Src is shown to form a complex with HDAC3 at the plasma membrane and to use HDAC3 as a substrate for phosphorylation. Our results describe a novel localization and binding partner for the HDAC3 protein, as well as implicate c-Src in HDAC3 regulation.

References

Apr 28, 1994·Nature·S FumagalliS A Courtneidge
Mar 4, 2000·The EMBO Journal·X M ZhengD Shalloway
Jun 14, 2000·Archives of Biochemistry and Biophysics·L A MacMillan-CrowJ A Thompson
May 2, 2001·The Journal of Biological Chemistry·S M EllerbroekM S Stack
Jan 10, 2002·The Journal of Biological Chemistry·Wen-Ming YangEdward Seto
May 25, 2002·Nature·Charlotte HubbertTso-Pang Yao
Nov 12, 2002·The EMBO Journal·Akihiro ItoTso-Pang Yao
Apr 5, 2003·The Journal of Biological Chemistry·Karim DibTommy Andersson
May 1, 2004·The Journal of Cell Biology·Carolyn N WrobelJoan S Brugge
Aug 5, 2004·The Journal of Biological Chemistry·Barbara Olszewska-PazdrakMark R Hellmich
Aug 5, 2004·The Journal of Biological Chemistry·Tania M SchroederJennifer J Westendorf
Oct 27, 2004·Biochemical and Biophysical Research Communications·Robert Roskoski
Apr 30, 2005·The EMBO Journal·Michelle S LongworthLaimonis A Laimins

❮ Previous
Next ❯

Citations

Jun 22, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yoshihiro MinamiyaJunichi Ogawa
Feb 28, 2007·Cell Research·Paola GallinariChristian Steinkühler
Aug 19, 2007·Oncogene·P Karagianni, J Wong
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fabien GuidezDavid Grimwade
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jin Liu, Ruth Nussinov
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thi Lien-Anh NguyênJohn Hiscott
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pablo J Fernandez-MarcosMaria T Diaz-Meco
Oct 27, 2011·The Journal of Biological Chemistry·Saydul AlamLingfang Zeng
Jun 9, 2012·The Journal of Biological Chemistry·Youngmi KimDooil Jeoung
Feb 3, 2009·Cardiovascular Research·Sanjiv DhingraPawan K Singal
May 28, 2010·BMC Neuroscience·Heather R PelzelRobert W Nickells
Dec 25, 2013·PLoS Computational Biology·Evan J MolinelliChris Sander
Feb 27, 2009·Future Oncology·Renato Baserga
Jul 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Sridurga Mithraprabhu, Kate L Loveland
Mar 22, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akiko SuzukiKen Okumura
Dec 15, 2010·Journal of Biomedicine & Biotechnology·Karin SadoulSaadi Khochbin
Jan 31, 2008·Expert Opinion on Investigational Drugs·Eric HahnenIngmar Blümcke
Sep 29, 2009·Expert Opinion on Investigational Drugs·Ina OehmeOlaf Witt
Mar 8, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Michael J Morris, Lisa M Monteggia
Jul 17, 2012·Alcohol·Marisela AgudeloMadhavan P Nair
Jul 21, 2012·Biochimica Et Biophysica Acta·Carola ParolinGiorgio Sartor
Apr 28, 2011·Neurobiology of Learning and Memory·Susan C McQuown, Marcelo A Wood
Oct 20, 2009·European Journal of Pharmacology·Lasse Sommer KristensenLise Lotte Hansen
Mar 21, 2015·Journal of Molecular and Cellular Cardiology·Bradley S Ferguson, Timothy A McKinsey
Mar 27, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ole Ammerpohl, Holger Kalthoff
Jul 27, 2011·Biochemical Society Transactions·Alexander J P Edwards, Sylvia L F Pender
Oct 12, 2014·Human Molecular Genetics·Hyo-Kyoung ChoiHo-Geun Yoon
Feb 25, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Matthew S Stratton, Timothy A McKinsey
Aug 22, 2014·PloS One·Kyung Ah HanKwang Chul Chung
Aug 25, 2016·BioMed Research International·Elizabeth E HullKathryn J Leyva
Oct 18, 2016·Journal of Molecular Graphics & Modelling·Malihe HassanzadehMassoud Amanlou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.